2,2-Dimethoxypropane
In-game article clicks load inline without leaving the challenge.
2,2-Dimethoxypropane (DMP) is an organic compound with the formula (CH3)2C(OCH3)2. A colorless liquid, it is the product of the condensation of acetone and methanol. DMP is used as a water scavenger in water-sensitive reactions. Upon acid-catalyzed reaction, DMP reacts quantitatively with water to form acetone and methanol. This property can be used to accurately determine the amount of water in a sample, alternatively to the Karl Fischer method.
DMP is used to prepare acetonides from diols, where it is both a synthon for acetone and a scavenger for the water byproduct:
RCHOHCHOHCH2 + (CH3O)2C(CH3)2 → RCHCHCH2O2C(CH3)2 + 2 CH3OH
It can also be used to prepare methyl esters from carboxylic acids, where it acts as a water scavenger and source of methanol:
RCOOH + CH3OH → RCOOCH3 + H2O
H2O + (CH3)2C(OCH3)2 —> 2CH3OH + (CH3)2C(O)
Dimethoxypropane is an intermediate for the synthesis of 2-methoxypropene.
In histology, DMP is used for the dehydration of animal tissue.