| Exhibition |
| 11/3/2009* 7:00pm | No. 21 | Ferris State | W 62–51 | — | UD Arena Dayton, Ohio |
| 11/9/2009* 7:00pm | No. 21 | Northern Kentucky | W 71–61 | — | UD Arena Dayton, Ohio |
| Regular Season |
| 11/14/2009* 1:00pm,WHIO | No. 21 | Creighton | W 90–80 | 1–0 | UD Arena (13,435) Dayton, Ohio |
| 11/19/2009* 11:30am,ESPN Plus | No. 18 | vs. No. 21 Georgia Tech Puerto Rico Tip-Off | W 63–59 | 2–0 | José Miguel Agrelot Coliseum (5,073) San Juan, PR |
| 11/20/2009* 3:30pm,ESPNU | No. 18 | vs. No. 5 Villanova Puerto Rico Tip-Off | L 65–71 | 2–1 | José Miguel Agrelot Coliseum (5,762) San Juan, PR |
| 11/22/2009* 5:30pm,ESPNU | No. 18 | vs. Kansas State Puerto Rico Tip-Off | L 75–83 | 2–2 | José Miguel Agrelot Coliseum (8,357) San Juan, PR |
| 11/28/2009* 2:00pm | | Towson | W 74–69 | 3–2 | UD Arena (12,730) Dayton, Ohio |
| 12/2/2009* 7:05pm,WHIO | | at Miami (OH) | W 65–58 | 4–2 | Millett Hall (4,820) Oxford, Ohio |
| 12/5/2009* 2:00pm | | Lehigh | W 89–71 | 5–2 | UD Arena (12,719) Dayton, Ohio |
| 12/8/2009* 7:00pm,WHIO | | at George Mason | W 56–55 | 6–2 | Patriot Center (5,727) Fairfax, Virginia |
| December 11, 2009* 7:00pm,WHIO | | Old Dominion | W 58–50 | 7–2 | UD Arena (13,159) Dayton, Ohio |
| 12/19/2009* 8:00pm | | Presbyterian | W 71–52 | 8–2 | UD Arena (12,269) Dayton, Ohio |
| 12/21/2009* 8:00pm | | Appalachian State | W 65–49 | 9–2 | UD Arena (13,435) Dayton, Ohio |
| 12/29/2009* 7:00pm | | Boston University | W 74–60 | 10–2 | UD Arena (13,435) Dayton, Ohio |
| 1/1/2010* 9:00pm,CBSCS | | at No. 19 New Mexico | L 66–68 | 10–3 | The Pit (14,586) Albuquerque, New Mexico |
| 1/5/2010* 8:00pm | | at Ball State | W 59–35 | 11–3 | UD Arena (13,167) Dayton, Ohio |
| 1/9/2010 2:00pm,CBSCS | | Duquesne | W 78–72 | 12–3 (1–0) | UD Arena (13,435) Dayton, Ohio |
| 1/13/2010 9:30pm,WHIO | | at Fordham | W 74–58 | 13–3 (2–0) | Madison Square Garden (7,040) New York City |
| 1/16/2010 11:00am,ESPN2 | | at Xavier | L 75–78 | 13–4 (2–1) | Cintas Center (10,250) Cincinnati, Ohio |
| 1/20/2010 7:00pm | | George Washington | W 66–51 | 14–4 (3–1) | UD Arena (12,630) Dayton, Ohio |
| 1/23/2010 6:00pm,ESPNU | | at Saint Joseph's | L 59–60 | 14–5 (3–2) | Hagan Arena (4,200) Philadelphia, Pennsylvania |
| 1/26/2010 7:00pm,WHIO | | Rhode Island | L 64–65 | 14–6 (3–3) | UD Arena (12,501) Dayton, Ohio |
| 1/30/2010 7:00pm | | at St. Bonaventure | W 75–58 | 15–6 (4–3) | Reilly Center (5,290) St. Bonaventure, New York |
| 2/6/2010 11:00am,ESPN2 | | Xavier | W 90–65 | 16–6 (5–3) | UD Arena (13,435) Dayton, Ohio |
| February 10, 2010 7:00pm | | Charlotte | W 75–47 | 17–6 (6–3) | UD Arena (12,716) Dayton, Ohio |
| 2/13/2010 4:00pm,ESPNU | | at Saint Louis | L 65–68 2OT | 17–7 (6–4) | Chaifetz Arena (9,453) St. Louis, Missouri |
| 2/18/2010 7:00pm,CBSCS | | La Salle | W 68–54 | 18–7 (7–4) | UD Arena (12,664) Dayton, Ohio |
| 2/21/2010 1:00pm,ESPN2 | | at Duquesne | L 71–73 | 18–8 (7–5) | A. J. Palumbo Center (5,144) Pittsburgh, Pennsylvania |
| 2/24/2010 6:30pm,CBSCS | | at No. 20 Temple | L 41–49 | 18–9 (7–6) | Liacouras Center (5,833) Philadelphia, Pennsylvania |
| 2/27/2010 7:00pm,CBSCS | | UMass | W 96–68 | 19–9 (8–6) | UD Arena (13,435) Dayton, Ohio |
| 3/4/2010 7:00pm,CBSCS | | at Richmond | L 56–60 | 19–10 (8–7) | Robins Center (7,121) Richmond, Virginia |
| 3/6/2010 7:00pm,CBSCS | | Saint Louis | L 66–71 | 19–11 (8–8) | UD Arena (13,435) Dayton, Ohio |
| Atlantic 10 tournament |
| 3/9/2010 7:00pm | (7) | (10) George Washington A-10 First Round | W 70–60 | 20–11 | UD Arena (6,930) Dayton, Ohio |
| March 12, 2010 6:30pm,CBSCS | (7) | vs. (2) No. 24 Xavier A-10 Quarterfinals | L 73–78 | 20–12 | Boardwalk Hall Atlantic City, New Jersey |
| NIT |
| 3/17/2010 7:00pm | (3 I) | (6 I) Illinois State NIT First Round | W 63–42 | 21–12 | UD Arena (5,127) Dayton, Ohio |
| 3/22/2010 9:00pm,ESPN | (3 I) | at (2 I) Cincinnati NIT Second Round | W 81–66 | 22–12 | Fifth Third Arena (6,479) Cincinnati, Ohio |
| 3/24/2010 9:00pm,ESPN2 | (3 I) | at (1 I) Illinois NIT Quarterfinals | W 77–71 | 23–12 | Assembly Hall (8,548) Champaign, Illinois |
| 3/30/2010 7:00pm,ESPN2 | (3 I) | vs. (2 AS) Ole Miss NIT Semifinals | W 68–63 | 24–12 | Madison Square Garden (11,689) New York City |
| 4/1/2010 7:00pm,ESPN | (3 I) | vs. (4 MS) North Carolina NIT Championship Game | W 79–68 | 25–12 | Madison Square Garden (9,827) New York |
| *Non-conference game. #Rankings from AP Poll. (#) Tournament seedings in parentheses. AS=NIT Arizona State bracket. I=NIT Illinois bracket. MS=NIT Mississippi State bracket. All times are in Eastern Time. Source |