2016 US Open – Mixed doubles
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Laura Siegemund and Mate Pavić won the title, defeating Vandeweghe and Ram in the final, 6–4, 6–4.
Martina Hingis and Leander Paes were the defending champions, but lost in the second round to CoCo Vandeweghe and Rajeev Ram.
Seeds
- India Sania Mirza / Croatia Ivan Dodig (second round)
- Kazakhstan Yaroslava Shvedova / Brazil Bruno Soares (quarterfinals)
- United States Bethanie Mattek-Sands / Romania Horia Tecău (withdrew)
- United States Raquel Atawo / Netherlands Jean-Julien Rojer (first round)
- Chinese Taipei Chan Hao-ching / Belarus Max Mirnyi (second round)
- Czech Republic Andrea Hlaváčková / Poland Łukasz Kubot (second round)
- United States CoCo Vandeweghe / United States Rajeev Ram (final)
- Czech Republic Lucie Hradecká / Poland Marcin Matkowski (first round)
Draw
Key
- Q = Qualifier
- WC = Wild card
- LL = Lucky loser
- Alt = Alternate
- ITF = ITF entry
- PR = Protected ranking
- SR = Special ranking
- SE = Special exempt
- JE = Junior exempt
- JR = Junior Accelerator Programme entrant
- CO = College Accelerator Programme entrant
- NG = Next Gen Accelerator Program entrant
- w/o = Walkover
- r = Retired
- d = Defaulted
Finals
Top half
Bottom half
Other entry information
Wild cards
- United States Emina Bektas / United States Evan King
- United States Nicole Gibbs / United States Dennis Novikov
- Switzerland Martina Hingis / India Leander Paes
- United States Jamie Loeb / United States Noah Rubin
- United States Christina McHale / United States Ryan Harrison
- United States Melanie Oudin / United States Mitchell Krueger
- United States Taylor Townsend / United States Donald Young
- United States Sachia Vickery / United States Frances Tiafoe