| Regular season |
| February Date Opponent Rank Site/stadium Score Win Loss Save Attendance Overall record ACC record February 27 at Wake Forest David F. Couch Ballpark • Winston-Salem, NC 8–10 Cole McNamee (1–0) Tanner Kohlhepp (0–1) Camden Minacci (2) 233 0–1 0–1 February 27 at Wake Forest David F. Couch Ballpark • Winston-Salem, NC 5–4 Liam Simon (1–0) Crawford Wade (0–1) Aidan Tyrell (1) 278 1–1 1–1 February 28 at Wake Forest David F. Couch Ballpark • Winston-Salem, NC 10–0 Christian Scafidi (1–0) Shane Smith (0–1) Alex Rao (1) 401 2–1 2–1 |
| Date | Opponent | Rank | Site/stadium | Score | Win | Loss | Save | Attendance | Overall record | ACC record |
| February 27 | at Wake Forest | | David F. Couch Ballpark • Winston-Salem, NC | 8–10 | Cole McNamee (1–0) | Tanner Kohlhepp (0–1) | Camden Minacci (2) | 233 | 0–1 | 0–1 |
| February 27 | at Wake Forest | | David F. Couch Ballpark • Winston-Salem, NC | 5–4 | Liam Simon (1–0) | Crawford Wade (0–1) | Aidan Tyrell (1) | 278 | 1–1 | 1–1 |
| February 28 | at Wake Forest | | David F. Couch Ballpark • Winston-Salem, NC | 10–0 | Christian Scafidi (1–0) | Shane Smith (0–1) | Alex Rao (1) | 401 | 2–1 | 2–1 |
| March Date Opponent Rank Site/stadium Score Win Loss Save Attendance Overall record ACC record March 5 at Clemson Doug Kingsmore Stadium • Clemson, SC 7–13 Davis Sharpe (2–0) Tommy Sheehan (0–1) 1,280 2–2 2–2 March 6 at Clemson Doug Kingsmore Stadium • Clemson, SC 3–1 John Michael Bertrand (1–0) Ty Olenchuk (1–1) Will Mercer (1) 1,280 3–2 3–2 March 7 at Clemson Doug Kingsmore Stadium • Clemson, SC 3–2 Liam Simon (2–0) Mack Anglin (0–1) Jack Brannigan (1) 1,280 4–2 4–2 March 12 at Virginia Davenport Field • Charlottesville, VA 10–5 Liam Simon (3–0) Andrew Abbott (1–3) Joe Sheridan (1) 221 5–2 5–2 March 13 at Virginia Davenport Field • Charlottesville, VA 12–4 John Michael Bertrand (2–0) Paul Kosanovich (0–1) 354 6–2 6–2 March 14 at Virginia Davenport Field • Charlottesville, VA 8–3 Aidan Tyrell (1–0) Mike Vasil (3–1) Tanner Kohlhepp (1) 350 7–2 7–2 March 19 Duke No. 23 Frank Eck Stadium • Notre Dame, IN 6–4 (13) Tanner Kohlhepp (1–1) Matt Dockman (0–1) 210 8–2 8–2 March 20 Duke No. 23 Frank Eck Stadium • Notre Dame, IN 6–2 John Michael Bertrand (3–0) Henry Williams (2–1) 275 9–2 9–2 March 21 Duke No. 23 Frank Eck Stadium • Notre Dame, IN 0–2 Jack Carey (1–0) Aidan Tyrell (1–1) Marcus Johnson (2) 300 9–3 9–3 March 23 Valparaiso No. 21 Frank Eck Stadium • Notre Dame, IN 6–3 Will Mercer (1–0) Easton Rhodehouse (1–1) Liam Simon (1) 75 10–3 March 26 No. 7 Louisville No. 21 Frank Eck Stadium • Notre Dame, IN 4–7 Adam Elliott (3–1) Joe Sheridan (0–1) Kaleb Corbett (4) 301 10–4 9–4 March 27 No. 7 Louisville No. 21 Frank Eck Stadium • Notre Dame, IN 5–3 Jack Brannigan (1–0) Tate Kuehner (1–3) 315 11–4 10–4 |
| Date | Opponent | Rank | Site/stadium | Score | Win | Loss | Save | Attendance | Overall record | ACC record |
| March 5 | at Clemson | | Doug Kingsmore Stadium • Clemson, SC | 7–13 | Davis Sharpe (2–0) | Tommy Sheehan (0–1) | | 1,280 | 2–2 | 2–2 |
| March 6 | at Clemson | | Doug Kingsmore Stadium • Clemson, SC | 3–1 | John Michael Bertrand (1–0) | Ty Olenchuk (1–1) | Will Mercer (1) | 1,280 | 3–2 | 3–2 |
| March 7 | at Clemson | | Doug Kingsmore Stadium • Clemson, SC | 3–2 | Liam Simon (2–0) | Mack Anglin (0–1) | Jack Brannigan (1) | 1,280 | 4–2 | 4–2 |
| March 12 | at Virginia | | Davenport Field • Charlottesville, VA | 10–5 | Liam Simon (3–0) | Andrew Abbott (1–3) | Joe Sheridan (1) | 221 | 5–2 | 5–2 |
| March 13 | at Virginia | | Davenport Field • Charlottesville, VA | 12–4 | John Michael Bertrand (2–0) | Paul Kosanovich (0–1) | | 354 | 6–2 | 6–2 |
| March 14 | at Virginia | | Davenport Field • Charlottesville, VA | 8–3 | Aidan Tyrell (1–0) | Mike Vasil (3–1) | Tanner Kohlhepp (1) | 350 | 7–2 | 7–2 |
| March 19 | Duke | No. 23 | Frank Eck Stadium • Notre Dame, IN | 6–4 (13) | Tanner Kohlhepp (1–1) | Matt Dockman (0–1) | | 210 | 8–2 | 8–2 |
| March 20 | Duke | No. 23 | Frank Eck Stadium • Notre Dame, IN | 6–2 | John Michael Bertrand (3–0) | Henry Williams (2–1) | | 275 | 9–2 | 9–2 |
| March 21 | Duke | No. 23 | Frank Eck Stadium • Notre Dame, IN | 0–2 | Jack Carey (1–0) | Aidan Tyrell (1–1) | Marcus Johnson (2) | 300 | 9–3 | 9–3 |
| March 23 | Valparaiso | No. 21 | Frank Eck Stadium • Notre Dame, IN | 6–3 | Will Mercer (1–0) | Easton Rhodehouse (1–1) | Liam Simon (1) | 75 | 10–3 | |
| March 26 | No. 7 Louisville | No. 21 | Frank Eck Stadium • Notre Dame, IN | 4–7 | Adam Elliott (3–1) | Joe Sheridan (0–1) | Kaleb Corbett (4) | 301 | 10–4 | 9–4 |
| March 27 | No. 7 Louisville | No. 21 | Frank Eck Stadium • Notre Dame, IN | 5–3 | Jack Brannigan (1–0) | Tate Kuehner (1–3) | | 315 | 11–4 | 10–4 |
| April Date Opponent Rank Site/stadium Score Win Loss Save Attendance Overall record ACC record April 3 at Pittsburgh No. 17 Charles L. Cost Field • Pittsburgh, PA 4–1 Tanner Kohlhepp (2–1) Mitch Myers (2–4) Joe Sheridan (2) 55 12–4 11–4 April 4 at Pittsburgh No. 17 Charles L. Cost Field • Pittsburgh, PA 2–3 Jordan McCrum (2–1) Liam Simon (3–1) 210 12–5 11–5 April 5 at Pittsburgh No. 19 Charles L. Cost Field • Pittsburgh, PA 11–5 Tanner Kohlhepp (3–1) Stephen Hansen (1–1) 210 13–5 12–5 April 9 No. 22 Georgia Tech No. 19 Frank Eck Stadium • Notre Dame, IN 10–9 Joe Sheridan (1–1) Zach Maxwell (0–1) 309 14–5 13–5 April 10 No. 22 Georgia Tech No. 19 Frank Eck Stadium • Notre Dame, IN 7–0 Aidan Tyrell (2–1) Andy Archer (4–3) Alex Rao (2) 152 15–5 14–5 April 11 No. 22 Georgia Tech No. 19 Frank Eck Stadium • Notre Dame, IN 2–4 Josiah Siegel (1–0) Joe Sheridan (1–2) Luke Bartnicki (4) 125 15–6 14–6 April 13 Central Michigan No. 16 Frank Eck Stadium • Notre Dame, IN 8–4 Alex Rao (1–0) J.T. Rogoszewski (1–2) 116 16–6 April 16 NC State No. 16 Frank Eck Stadium • Notre Dame, IN 3–2 Tanner Kohlhepp (4–1) Reid Johnston (3–2) 279 17–6 15–6 April 17 NC State No. 16 Frank Eck Stadium • Notre Dame, IN 2–5 Sam Highfill (3–2) John Michael Bertrand (3–1) Evan Justice (2) 237 17–7 15–7 April 18 NC State No. 16 Frank Eck Stadium • Notre Dame, IN 11–2 Tanner Kohlhepp (5–1) Matt Willadsen (3–1) Joe Sheridan (3) 188 18–7 16–7 April 23 at Boston College No. 14 Pellagrini Diamond • Chestnut Hill, MA 0–10 Emmett Sheehan (4–3) Will Mercer (1–1) 150 18–8 16–8 April 24 at Boston College No. 14 Pellagrini Diamond • Chestnut Hill, MA 5–2 John Michael Bertrand (4–1) Mason Pelio (3–5) Tanner Kohlhepp (2) 150 19–8 17–8 April 24 at Boston College No. 14 Pellagrini Diamond • Chestnut Hill, MA 13–9 Liam Simon (4–1) Charlie Coon (1–2) 150 20–8 18–8 April 27 Valparaiso No. 14 Frank Eck Stadium • Notre Dame, IN 8–7 Liam Simon (5–1) Nathan Chasey (0–2) 97 21–8 April 30 North Carolina No. 14 Frank Eck Stadium • Notre Dame, IN 4–0 Tanner Kohlhepp (6–1) Austin Love (5–4) 175 22–8 19–8 |
| Date | Opponent | Rank | Site/stadium | Score | Win | Loss | Save | Attendance | Overall record | ACC record |
| April 3 | at Pittsburgh | No. 17 | Charles L. Cost Field • Pittsburgh, PA | 4–1 | Tanner Kohlhepp (2–1) | Mitch Myers (2–4) | Joe Sheridan (2) | 55 | 12–4 | 11–4 |
| April 4 | at Pittsburgh | No. 17 | Charles L. Cost Field • Pittsburgh, PA | 2–3 | Jordan McCrum (2–1) | Liam Simon (3–1) | | 210 | 12–5 | 11–5 |
| April 5 | at Pittsburgh | No. 19 | Charles L. Cost Field • Pittsburgh, PA | 11–5 | Tanner Kohlhepp (3–1) | Stephen Hansen (1–1) | | 210 | 13–5 | 12–5 |
| April 9 | No. 22 Georgia Tech | No. 19 | Frank Eck Stadium • Notre Dame, IN | 10–9 | Joe Sheridan (1–1) | Zach Maxwell (0–1) | | 309 | 14–5 | 13–5 |
| April 10 | No. 22 Georgia Tech | No. 19 | Frank Eck Stadium • Notre Dame, IN | 7–0 | Aidan Tyrell (2–1) | Andy Archer (4–3) | Alex Rao (2) | 152 | 15–5 | 14–5 |
| April 11 | No. 22 Georgia Tech | No. 19 | Frank Eck Stadium • Notre Dame, IN | 2–4 | Josiah Siegel (1–0) | Joe Sheridan (1–2) | Luke Bartnicki (4) | 125 | 15–6 | 14–6 |
| April 13 | Central Michigan | No. 16 | Frank Eck Stadium • Notre Dame, IN | 8–4 | Alex Rao (1–0) | J.T. Rogoszewski (1–2) | | 116 | 16–6 | |
| April 16 | NC State | No. 16 | Frank Eck Stadium • Notre Dame, IN | 3–2 | Tanner Kohlhepp (4–1) | Reid Johnston (3–2) | | 279 | 17–6 | 15–6 |
| April 17 | NC State | No. 16 | Frank Eck Stadium • Notre Dame, IN | 2–5 | Sam Highfill (3–2) | John Michael Bertrand (3–1) | Evan Justice (2) | 237 | 17–7 | 15–7 |
| April 18 | NC State | No. 16 | Frank Eck Stadium • Notre Dame, IN | 11–2 | Tanner Kohlhepp (5–1) | Matt Willadsen (3–1) | Joe Sheridan (3) | 188 | 18–7 | 16–7 |
| April 23 | at Boston College | No. 14 | Pellagrini Diamond • Chestnut Hill, MA | 0–10 | Emmett Sheehan (4–3) | Will Mercer (1–1) | | 150 | 18–8 | 16–8 |
| April 24 | at Boston College | No. 14 | Pellagrini Diamond • Chestnut Hill, MA | 5–2 | John Michael Bertrand (4–1) | Mason Pelio (3–5) | Tanner Kohlhepp (2) | 150 | 19–8 | 17–8 |
| April 24 | at Boston College | No. 14 | Pellagrini Diamond • Chestnut Hill, MA | 13–9 | Liam Simon (4–1) | Charlie Coon (1–2) | | 150 | 20–8 | 18–8 |
| April 27 | Valparaiso | No. 14 | Frank Eck Stadium • Notre Dame, IN | 8–7 | Liam Simon (5–1) | Nathan Chasey (0–2) | | 97 | 21–8 | |
| April 30 | North Carolina | No. 14 | Frank Eck Stadium • Notre Dame, IN | 4–0 | Tanner Kohlhepp (6–1) | Austin Love (5–4) | | 175 | 22–8 | 19–8 |
| May Date Opponent Rank Site/stadium Score Win Loss Save Attendance Overall record ACC record May 1 North Carolina No. 14 Frank Eck Stadium • Notre Dame, IN 13–12 John Michael Bertrand (5–1) Shawn Rapp (1–1) Aidan Tyrell (2) 274 23–8 20–8 May 2 North Carolina No. 14 Frank Eck Stadium • Notre Dame, IN 19–5 Tanner Kohlhepp (7–1) Gage Gillian (1–1) 275 24–8 21–8 May 7 Florida State No. 10 Frank Eck Stadium • Notre Dame, IN 2–5 Parker Messick (6–2) Will Mercer (1–2) Jack Anderson (3) 358 24–9 21–9 May 8 Florida State No. 10 Frank Eck Stadium • Notre Dame, IN 5–3 John Michael Bertrand (6–1) Bryce Hubbart (5–4) Jack Brannigan (2) 302 25–9 22–9 May 8 Florida State No. 10 Frank Eck Stadium • Notre Dame, IN 1–7 Conor Grady (5–2) Alex Rao (1–1) 302 25–10 22–10 May 11 at Valparaiso No. 15 Emory G. Bauer Field • Valparaiso, IN 7–4 Will Mercer (2–2) Easton Rhodehouse (3–3) 70 26–10 May 20 at Virginia Tech No. 13 English Field • Blacksburg, VA 8–2 John Michael Bertrand (7–1) Peyton Alford (2–5) 448 27–10 23–10 May 21 at Virginia Tech No. 13 English Field • Blacksburg, VA 4–0 Aidan Tyrell (3–1) Anthony Simonelli (5–2) Jack Brannigan (3) 664 28–10 24–10 May 22 at Virginia Tech No. 13 English Field • Blacksburg, VA 7–1 Alex Rao (2–1) Ryan Okuda (2–3) Will Mercer (2) 619 29–10 25–10 |
| Date | Opponent | Rank | Site/stadium | Score | Win | Loss | Save | Attendance | Overall record | ACC record |
| May 1 | North Carolina | No. 14 | Frank Eck Stadium • Notre Dame, IN | 13–12 | John Michael Bertrand (5–1) | Shawn Rapp (1–1) | Aidan Tyrell (2) | 274 | 23–8 | 20–8 |
| May 2 | North Carolina | No. 14 | Frank Eck Stadium • Notre Dame, IN | 19–5 | Tanner Kohlhepp (7–1) | Gage Gillian (1–1) | | 275 | 24–8 | 21–8 |
| May 7 | Florida State | No. 10 | Frank Eck Stadium • Notre Dame, IN | 2–5 | Parker Messick (6–2) | Will Mercer (1–2) | Jack Anderson (3) | 358 | 24–9 | 21–9 |
| May 8 | Florida State | No. 10 | Frank Eck Stadium • Notre Dame, IN | 5–3 | John Michael Bertrand (6–1) | Bryce Hubbart (5–4) | Jack Brannigan (2) | 302 | 25–9 | 22–9 |
| May 8 | Florida State | No. 10 | Frank Eck Stadium • Notre Dame, IN | 1–7 | Conor Grady (5–2) | Alex Rao (1–1) | | 302 | 25–10 | 22–10 |
| May 11 | at Valparaiso | No. 15 | Emory G. Bauer Field • Valparaiso, IN | 7–4 | Will Mercer (2–2) | Easton Rhodehouse (3–3) | | 70 | 26–10 | |
| May 20 | at Virginia Tech | No. 13 | English Field • Blacksburg, VA | 8–2 | John Michael Bertrand (7–1) | Peyton Alford (2–5) | | 448 | 27–10 | 23–10 |
| May 21 | at Virginia Tech | No. 13 | English Field • Blacksburg, VA | 4–0 | Aidan Tyrell (3–1) | Anthony Simonelli (5–2) | Jack Brannigan (3) | 664 | 28–10 | 24–10 |
| May 22 | at Virginia Tech | No. 13 | English Field • Blacksburg, VA | 7–1 | Alex Rao (2–1) | Ryan Okuda (2–3) | Will Mercer (2) | 619 | 29–10 | 25–10 |
| Postseason |
| ACC Tournament Date Opponent Rank Site/stadium Score Win Loss Save Attendance Overall record ACCT record May 26 vs. Virginia Tech No. 7 Truist Field • Charlotte, NC 8–0 Will Mercer (3–2) Jaison Heard (3–4) 3,020 30–10 1–0 May 28 vs. Virginia No. 7 Truist Field • Charlotte, NC 1–14 Andrew Abbott (8–5) John Michael Bertrand (7–2) 30–11 1–1 |
| Date | Opponent | Rank | Site/stadium | Score | Win | Loss | Save | Attendance | Overall record | ACCT record |
| May 26 | vs. Virginia Tech | No. 7 | Truist Field • Charlotte, NC | 8–0 | Will Mercer (3–2) | Jaison Heard (3–4) | | 3,020 | 30–10 | 1–0 |
| May 28 | vs. Virginia | No. 7 | Truist Field • Charlotte, NC | 1–14 | Andrew Abbott (8–5) | John Michael Bertrand (7–2) | | | 30–11 | 1–1 |
| NCAA tournament: South Bend Regional Date Opponent Rank Site/stadium Score Win Loss Save Attendance Overall record NCAAT record June 4 vs. No. 26 Central Michigan No. 7 Frank Eck Stadium • Notre Dame, IN 10–0 John Michael Bertrand (8–2) Andrew Taylor (11–4) 1,825 31–11 1–0 |
| Date | Opponent | Rank | Site/stadium | Score | Win | Loss | Save | Attendance | Overall record | NCAAT record |
| June 4 | vs. No. 26 Central Michigan | No. 7 | Frank Eck Stadium • Notre Dame, IN | 10–0 | John Michael Bertrand (8–2) | Andrew Taylor (11–4) | | 1,825 | 31–11 | 1–0 |
| All rankings from Collegiate Baseball. |