The 2022 Play In Challenger was a professional tennis tournament played on indoor hard courts. It was the fourth edition of the tournament, which was part of the 2022 ATP Challenger Tour. It took place in Lille, France, between 21 and 27 March 2022.

Singles main-draw entrants

Seeds

CountryPlayerRank1Seed
LTURičardas Berankis841
FRAQuentin Halys1132
BIHDamir Džumhur1373
Roman Safiullin1434
FRAGrégoire Barrère1725
FRAEnzo Couacaud1816
BELZizou Bergs1827
FRAConstant Lestienne1988
  • 1 Rankings are as of 14 March 2022.

Other entrants

The following players received wildcards into the singles main draw:

The following players received entry into the singles main draw using protected rankings:

The following players received entry from the qualifying draw:

Champions

Singles

Doubles