25CN-NBOMe
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25CN-NBOMe, also known as 2C-CN-NBOMe or NBOMe-2C-CN, is a derivative of the phenethylamine 2C-CN. It acts in a similar manner to related compounds such as 25I-NBOMe, which are potent agonists at the serotonin 5-HT2A receptor.
Interactions
Pharmacology
Pharmacodynamics
| Target | Affinity (Ki, nM) |
|---|---|
| 5-HT1A | ND |
| 5-HT1B | ND |
| 5-HT1D | ND |
| 5-HT1E | ND |
| 5-HT1F | ND |
| 5-HT2A | 1.8–4.6 (Ki) 0.40–6.7 (EC50Tooltip half-maximal effective concentration) 77–148% (EmaxTooltip maximal efficacy) |
| 5-HT2B | 21–47 (Ki) 12 (EC50) 79% (Emax) |
| 5-HT2C | 8–180 (Ki) 9.3–230 (EC50) 91–101% (Emax) |
| 5-HT3 | ND |
| 5-HT4 | ND |
| 5-HT5A | ND |
| 5-HT6 | 145 |
| 5-HT7 | ND |
| α1A–α1D | ND |
| α2A–α2C | ND |
| β1–β3 | ND |
| D1–D5 | ND |
| H1–H4 | ND |
| M1–M5 | ND |
| I1 | ND |
| σ1, σ2 | ND |
| ORs | ND |
| TAAR1Tooltip Trace amine-associated receptor 1 | ND |
| SERTTooltip Serotonin transporter | ND (Ki) ND (IC50Tooltip half-maximal inhibitory concentration) ND (EC50) |
| NETTooltip Norepinephrine transporter | ND (Ki) ND (IC50) ND (EC50) |
| DATTooltip Dopamine transporter | ND (Ki) ND (IC50) ND (EC50) |
| Notes: The smaller the value, the more avidly the drug binds to the site. All proteins are human unless otherwise specified. Refs: |
25CN-NBOMe acts as a potent and selective agonist of the serotonin 5-HT2A receptor. To a lesser extent, it also acts as an agonist of the serotonin 5-HT2B and 5-HT2C receptors.
History
25CN-NBOMe was first described in the scientific literature by 2010.
Society and culture
Legal status
Canada
25CN-NBOMe is a controlled substance in Canada under phenethylamine blanket-ban language.
United Kingdom
This substance is a Class A drug in the United Kingdom as a result of the N-benzylphenethylamine catch-all clause in the Misuse of Drugs Act 1971.