25T-NBOMe
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25T-NBOMe, also known as 2C-T-NBOMe or NBOMe-2C-T as well as N-(2-methoxybenzyl)-4-methylthio-2,5-dimethoxyphenethylamine, is a serotonin 5-HT2 receptor agonist and possible serotonergic psychedelic of the phenethylamine, 2C, and 25-NB (NBOMe) families. It is the NBOMe (N-(2-methoxybenzyl)) derivative of 2C-T.
Interactions
Pharmacology
Pharmacodynamics
| Target | Affinity (Ki, nM) |
|---|---|
| 5-HT1A | ND |
| 5-HT1B | 3,385 |
| 5-HT1D | ND |
| 5-HT1E | ND |
| 5-HT1F | ND |
| 5-HT2A | 0.54 (Ki) 2.0–4.2 (EC50Tooltip half-maximal effective concentration) 86–179% (EmaxTooltip maximal efficacy) |
| 5-HT2B | 0.91 (Ki) ND (EC50) ND (Emax) |
| 5-HT2C | 7.4 (Ki) (rat) 21.4 (EC50) 103% (Emax) |
| 5-HT3 | ND |
| 5-HT4 | ND |
| 5-HT5A | ND |
| 5-HT6 | 117 |
| 5-HT7 | ND |
| α1A–α1D | ND |
| α2A–α2C | ND |
| β1–β3 | ND |
| D1–D5 | ND |
| H1–H4 | ND |
| M1–M5 | ND |
| I1 | ND |
| σ1, σ2 | ND |
| ORs | ND |
| TAAR1Tooltip Trace amine-associated receptor 1 | ND |
| SERTTooltip Serotonin transporter | ND (Ki) ND (IC50Tooltip half-maximal inhibitory concentration) ND (EC50) |
| NETTooltip Norepinephrine transporter | ND (Ki) ND (IC50) ND (EC50) |
| DATTooltip Dopamine transporter | ND (Ki) ND (IC50) ND (EC50) |
| Notes: The smaller the value, the more avidly the drug binds to the site. All proteins are human unless otherwise specified. Refs: |
25T-NBOMe acts as a potent agonist of the serotonin 5-HT2A and 5-HT2C receptors and also shows interactions with certain other targets, such as the serotonin 5-HT2B receptor.
History
25T-NBOMe was first described in the scientific literature by 2010.
Society and culture
Legal status
Canada
25T-NBOMe is a controlled substance in Canada under phenethylamine blanket-ban language.