Adenosine A3 receptor

ADORA3

Available structuresPDBOrtholog search:List of PDB id codes,

Available structures

PDBOrtholog search:

List of PDB id codes,

List of PDB id codes

Identifiers

Aliases, A3AR, AD026, bA552M11.5, adenosine A3 receptor

External IDsOMIM: ; MGI: ; HomoloGene: ; GeneCards: ; OMA:

Gene location ( Human )

Chr.Chromosome 1 (human)

Band 1p13.2 Start 111,499,429 bp

End111,503,633 bp

Gene location ( Mouse )

Chr.Chromosome 3 (mouse)

Band 3 F2.2|3 46.45 cM Start 105,778,174 bp

End105,816,242 bp

RNA expression pattern

HumanMouse (ortholog)C1 segment right adrenal cortex left adrenal gland left adrenal cortex inferior ganglion of vagus nerve mucosa of transverse colon substantia nigra Descending thoracic aorta gallbladder internal globus pallidusgranulocyte spermatid embryo red pulp morula blastocyst lip dermis dentate gyrus of hippocampal formation granule cell superior frontal gyrus

Human Mouse (ortholog)

C1 segment right adrenal cortex left adrenal gland left adrenal cortex inferior ganglion of vagus nerve mucosa of transverse colon substantia nigra Descending thoracic aorta gallbladder internal globus pallidusgranulocyte spermatid embryo red pulp morula blastocyst lip dermis dentate gyrus of hippocampal formation granule cell superior frontal gyrus

granulocyte spermatid embryo red pulp morula blastocyst lip dermis dentate gyrus of hippocampal formation granule cell superior frontal gyrus

Gene ontologyMolecular functionCellular componentBiological processSources: /

Gene ontology

Molecular function

Cellular component

Biological process

Sources: /

OrthologsSpeciesHumanMouseEntrez Ensembl UniProtRefSeq (mRNA)RefSeq (protein)Location (UCSC)PubMed search

Orthologs

Species Human Mouse

Entrez

Ensembl

UniProt

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

PubMed search

Wikidata

View/Edit HumanView/Edit Mouse

The adenosine A3 receptor, also known as ADORA3, is an adenosine receptor, but also denotes the human gene encoding it.

Function

Adenosine A3 receptors are G protein-coupled receptors that couple to Gi/Gq and are involved in a variety of intracellular signaling pathways and physiological functions. It mediates a sustained cardioprotective function during cardiac ischemia, it is involved in the inhibition of neutrophil degranulation in neutrophil-mediated tissue injury, it has been implicated in both neuroprotective and neurodegenerative effects, and it may also mediate both cell proliferation and cell death[citation needed]. Recent publications demonstrate that adenosine A3 receptor antagonists (SSR161421) could have therapeutic potential in bronchial asthma (17,18).

Gene

Multiple transcript variants encoding different isoforms have been found for this gene.

Therapeutic implications

An adenosine A3 receptor agonist (CF-101) is in clinical trials for the treatment of rheumatoid arthritis. In a mouse model of infarction the A3 selective agonist CP-532,903 protected against myocardial ischemia and reperfusion injury.

Selective Ligands

A number of selective A3 ligands are available.

Agonists/Positive Allosteric Modulators

2-(1-Hexynyl)-N-methyladenosine
CF-101 (IB-MECA)/Piclidenoson
CF-102 (2-Cl-IB-MECA)/Namodenoson
CP-532,903
Inosine
LUF6000
MRS-3558
MRS7292
AST-004
CF 602

Antagonists/Negative Allosteric Modulators

KF-26777
MRS-545
MRS-1191
MRS-1220
MRS-1334
MRS-1523
MRS-3777
MRE-3005-F20
MRE-3008-F20
PSB-11
OT-7999
VUF-5574
SSR161421
ISAM-DM10

Inverse Agonists

PSB-10

External links

. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from on 2020-11-30.
Human genome location and gene details page in the UCSC Genome Browser.