ADAMTS8

Identifiers

Aliases, ADAM-TS8, METH2, ADAM metallopeptidase with thrombospondin type 1 motif 8

External IDsOMIM: ; MGI: ; HomoloGene: ; GeneCards: ; OMA:

Gene location ( Human )

Chr.Chromosome 11 (human)

Band 11q24.3 Start 130,404,923 bp

End130,428,609 bp

Gene location ( Mouse )

Chr.Chromosome 9 (mouse)

Band 9 A4|9 16.49 cM Start 30,853,858 bp

End30,875,134 bp

RNA expression patternHumanMouse (ortholog)middle temporal gyrus upper lobe of left lung endothelial cell lower lobe of lung right lung Brodmann area 23 entorhinal cortex tail of epididymis right coronary artery visceral pleuratunica media of zone of aorta lumbar spinal ganglion soleus muscle ankle atrium internal carotid artery endocardial cushion semi-lunar valve inner muscle layer tunica adventitia of aortan/a

RNA expression pattern

HumanMouse (ortholog)middle temporal gyrus upper lobe of left lung endothelial cell lower lobe of lung right lung Brodmann area 23 entorhinal cortex tail of epididymis right coronary artery visceral pleuratunica media of zone of aorta lumbar spinal ganglion soleus muscle ankle atrium internal carotid artery endocardial cushion semi-lunar valve inner muscle layer tunica adventitia of aorta

Human Mouse (ortholog)

middle temporal gyrus upper lobe of left lung endothelial cell lower lobe of lung right lung Brodmann area 23 entorhinal cortex tail of epididymis right coronary artery visceral pleuratunica media of zone of aorta lumbar spinal ganglion soleus muscle ankle atrium internal carotid artery endocardial cushion semi-lunar valve inner muscle layer tunica adventitia of aorta

middle temporal gyrus upper lobe of left lung endothelial cell lower lobe of lung right lung Brodmann area 23 entorhinal cortex tail of epididymis right coronary artery visceral pleura

tunica media of zone of aorta lumbar spinal ganglion soleus muscle ankle atrium internal carotid artery endocardial cushion semi-lunar valve inner muscle layer tunica adventitia of aorta

n/a

Gene ontologyMolecular functionCellular componentBiological processSources: /

Gene ontology

Molecular function

Cellular component

Biological process

Sources: /

OrthologsSpeciesHumanMouseEntrez Ensembl UniProtRefSeq (mRNA)RefSeq (protein)Location (UCSC)PubMed search

Orthologs

Species Human Mouse

Entrez

Ensembl

UniProt

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

PubMed search

Wikidata

View/Edit HumanView/Edit Mouse

A disintegrin and metalloproteinase with thrombospondin motifs 8 is an enzyme that in humans is encoded by the ADAMTS8 gene.

Function

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs, and disrupts angiogenesis in vivo.

Clinical significance

A number of disorders have been mapped in the vicinity of this gene, most notably lung neoplasms.

External links

The MEROPS online database for peptidases and their inhibitors:
Human genome location and gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

ADAMTS8

Function

Clinical significance

Further reading

External links