α-Ethylmescaline (AEM or 3,4,5-trimethoxy-α-ethylphenethylamine) is a chemical compound of the phenethylamine and phenylisobutylamine families related to the psychedelic drug mescaline. It is the analogue of mescaline and TMA with an ethyl group at the α position of the side chain.

Use and effects

In his book PiHKAL, Alexander Shulgin lists AEM's dose as greater than 220mg orally and its duration as unknown. It was found to be completely inactive in terms of both central and peripheral effects in humans.

Chemistry

Synthesis

The chemical synthesis of AEM has been described.

Derivatives

Alexander Shulgin never synthesized further α position-extended mescaline analogues, such as α-propylmescaline (APM) or α-butylmescaline (ABM), as the inactivity of AEM in humans discouraged him. In any case, APM and ABM have been found to be inactive in terms of induction of the head-twitch response, a behavioral proxy of psychedelic effects, in rodents, and hence may be non-hallucinogenic in humans as well.

History

AEM was first described in the scientific literature by Alexander Shulgin by 1963. He tested it and found it to be inactive in 1961. Later, Shulgin described AEM in greater detail in his 1991 book PiHKAL (Phenethylamines I Have Known and Loved).

See also

External links