AKAP6

Identifiers

Aliases, ADAP100, ADAP6, AKAP100, PRKA6, mAKAP, A-kinase anchoring protein 6

External IDsOMIM: ; MGI: ; HomoloGene: ; GeneCards: ; OMA:

Gene location ( Human )

Chr.Chromosome 14 (human)

Band 14q12 Start 32,329,298 bp

End32,837,684 bp

Gene location ( Mouse )

Chr.Chromosome 12 (mouse)

Band 12|12 C1 Start 52,746,166 bp

End53,202,382 bp

RNA expression patternHumanMouse (ortholog)gastrocnemius muscle prefrontal cortex muscle of thigh left ventricle ventricular zone Brodmann area 9 popliteal artery tibial arteries cingulate gyrus anterior cingulate cortexsuperior cervical ganglion trigeminal ganglion substantia nigra facial motor nucleus myocardium of ventricle extraocular muscle superior colliculus nucleus of stria terminalis Region I of hippocampus proper inferior colliculin/a

RNA expression pattern

HumanMouse (ortholog)gastrocnemius muscle prefrontal cortex muscle of thigh left ventricle ventricular zone Brodmann area 9 popliteal artery tibial arteries cingulate gyrus anterior cingulate cortexsuperior cervical ganglion trigeminal ganglion substantia nigra facial motor nucleus myocardium of ventricle extraocular muscle superior colliculus nucleus of stria terminalis Region I of hippocampus proper inferior colliculi

Human Mouse (ortholog)

gastrocnemius muscle prefrontal cortex muscle of thigh left ventricle ventricular zone Brodmann area 9 popliteal artery tibial arteries cingulate gyrus anterior cingulate cortexsuperior cervical ganglion trigeminal ganglion substantia nigra facial motor nucleus myocardium of ventricle extraocular muscle superior colliculus nucleus of stria terminalis Region I of hippocampus proper inferior colliculi

gastrocnemius muscle prefrontal cortex muscle of thigh left ventricle ventricular zone Brodmann area 9 popliteal artery tibial arteries cingulate gyrus anterior cingulate cortex

superior cervical ganglion trigeminal ganglion substantia nigra facial motor nucleus myocardium of ventricle extraocular muscle superior colliculus nucleus of stria terminalis Region I of hippocampus proper inferior colliculi

n/a

Gene ontologyMolecular functionCellular componentBiological processSources: /

Gene ontology

Molecular function

Cellular component

Biological process

Sources: /

OrthologsSpeciesHumanMouseEntrez Ensembl UniProtn/aRefSeq (mRNA)RefSeq (protein)n/aLocation (UCSC)PubMed search

Orthologs

Species Human Mouse

Entrez

Ensembl

UniProt n/a

n/a

RefSeq (mRNA)

RefSeq (protein) n/a

n/a

Location (UCSC)

PubMed search

Wikidata

View/Edit HumanView/Edit Mouse

A-kinase anchor protein 6 is an enzyme that in humans is encoded by the AKAP6 gene.

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is highly expressed in various brain regions and cardiac and skeletal muscle. It is specifically localized to the sarcoplasmic reticulum and nuclear membrane, and is involved in anchoring PKA to the nuclear membrane or sarcoplasmic reticulum.

Interactions

AKAP6 has been shown to interact with Ryanodine receptor 2 and PDE4D3.

External links

Human genome location and gene details page in the UCSC Genome Browser.

AKAP6

Interactions

External links

Further reading