ARFGEF1

Available structuresPDBOrtholog search:List of PDB id codes,

Available structures

PDBOrtholog search:

List of PDB id codes,

List of PDB id codes

Identifiers

Aliases, ARFGEP1, BIG1, P200, ADP ribosylation factor guanine nucleotide exchange factor 1

External IDsOMIM: ; MGI: ; HomoloGene: ; GeneCards: ; OMA:

Gene location ( Human )

Chr.Chromosome 8 (human)

Band 8q13.2 Start 67,173,511 bp

End67,343,781 bp

Gene location ( Mouse )

Chr.Chromosome 1 (mouse)

Band 1|1 A2 Start 10,207,796 bp

End10,302,895 bp

RNA expression pattern

HumanMouse (ortholog)gonad secondary oocyte epithelium of nasopharynx sural nerve bronchial epithelial cell testicle mucosa of sigmoid colon jejunal mucosa bone marrow tibiagastrula crypt of lieberkuhn of small intestine submandibular gland transitional epithelium of urinary bladder cumulus cell zygote knee joint triceps brachii muscle cardiac muscle tissue of left ventricle plantaris muscle

Human Mouse (ortholog)

gonad secondary oocyte epithelium of nasopharynx sural nerve bronchial epithelial cell testicle mucosa of sigmoid colon jejunal mucosa bone marrow tibiagastrula crypt of lieberkuhn of small intestine submandibular gland transitional epithelium of urinary bladder cumulus cell zygote knee joint triceps brachii muscle cardiac muscle tissue of left ventricle plantaris muscle

gonad secondary oocyte epithelium of nasopharynx sural nerve bronchial epithelial cell testicle mucosa of sigmoid colon jejunal mucosa bone marrow tibia

gastrula crypt of lieberkuhn of small intestine submandibular gland transitional epithelium of urinary bladder cumulus cell zygote knee joint triceps brachii muscle cardiac muscle tissue of left ventricle plantaris muscle

Gene ontologyMolecular functionCellular componentBiological processSources: /

Gene ontology

Molecular function

Cellular component

Biological process

Sources: /

OrthologsSpeciesHumanMouseEntrez Ensembl UniProtRefSeq (mRNA)RefSeq (protein)Location (UCSC)PubMed search

Orthologs

Species Human Mouse

Entrez

Ensembl

UniProt

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

PubMed search

Wikidata

View/Edit HumanView/Edit Mouse

Brefeldin A-inhibited guanine nucleotide-exchange protein 1 is a protein that in humans is encoded by the ARFGEF1 gene.

Function

ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP. It contains a Sec7 domain, which may be responsible for the guanine-nucleotide exchange activity and also the brefeldin A inhibition.

Interactions

ARFGEF1 has been shown to interact with FKBP2, ARFGEF2 and PRKAR1A.

External links

Human genome location and gene details page in the UCSC Genome Browser.

ARFGEF1

Function

Interactions

External links

Further reading