ATP2A2

Identifiers

Aliases, ATP2B, DAR, DD, SERCA2, ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2

External IDsOMIM: ; MGI: ; HomoloGene: ; GeneCards: ; OMA:

Gene location ( Human )

Chr.Chromosome 12 (human)

Band 12q24.11 Start 110,280,756 bp

End110,351,093 bp

Gene location ( Mouse )

Chr.Chromosome 5 (mouse)

Band 5 62.38 cM|5 F Start 122,591,576 bp

End122,640,288 bp

RNA expression patternHumanMouse (ortholog)Skeletal muscle tissue of biceps brachii right ventricle body of tongue triceps brachii muscle glutes Skeletal muscle tissue of rectus abdominis thoracic diaphragm right auricle of heart vena cava lateral nuclear group of thalamusmyocardium of ventricle atrium cardiac muscles cardiac muscle tissue of left ventricle interventricular septum medial dorsal nucleus atrioventricular valve soleus muscle right ventricle lateral geniculate nucleusn/a

RNA expression pattern

HumanMouse (ortholog)Skeletal muscle tissue of biceps brachii right ventricle body of tongue triceps brachii muscle glutes Skeletal muscle tissue of rectus abdominis thoracic diaphragm right auricle of heart vena cava lateral nuclear group of thalamusmyocardium of ventricle atrium cardiac muscles cardiac muscle tissue of left ventricle interventricular septum medial dorsal nucleus atrioventricular valve soleus muscle right ventricle lateral geniculate nucleus

Human Mouse (ortholog)

Skeletal muscle tissue of biceps brachii right ventricle body of tongue triceps brachii muscle glutes Skeletal muscle tissue of rectus abdominis thoracic diaphragm right auricle of heart vena cava lateral nuclear group of thalamusmyocardium of ventricle atrium cardiac muscles cardiac muscle tissue of left ventricle interventricular septum medial dorsal nucleus atrioventricular valve soleus muscle right ventricle lateral geniculate nucleus

myocardium of ventricle atrium cardiac muscles cardiac muscle tissue of left ventricle interventricular septum medial dorsal nucleus atrioventricular valve soleus muscle right ventricle lateral geniculate nucleus

n/a

Gene ontologyMolecular functionCellular componentBiological processSources: /

Gene ontology

Molecular function

Cellular component

Biological process

Sources: /

OrthologsSpeciesHumanMouseEntrez Ensembl UniProtRefSeq (mRNA)RefSeq (protein)Location (UCSC)PubMed search

Orthologs

Species Human Mouse

Entrez

Ensembl

UniProt

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

PubMed search

Wikidata

View/Edit HumanView/Edit Mouse

ATP2A2 also known as sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) is an ATPase associated with Darier's disease and Acrokeratosis verruciformis.

This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in calcium sequestration associated with muscular excitation and contraction. Alternative splicing results in multiple transcript variants encoding different isoforms.

External links

at the U.S. National Library of Medicine Medical Subject Headings (MeSH)