Afadin

Afadin is a protein that in humans is encoded by the AFDN gene.

Function

Afadin is a Ras (see HRAS; MIM 190020) target that regulates cell–cell adhesions downstream of Ras activation. It is fused with MLL (MIM 159555) in leukemias caused by t(6;11) translocations (Taya et al., 1998).[supplied by OMIM]

Interactions

Afadin has been shown to interact with:

• BCR gene,
• EPHB3,
• F11 receptor,
• HRAS and
• LMO2,
• PVRL1,
• PVRL3,
• Profilin 1,
• RAP1A,
• RAP1GAP,
• SORBS1,
• SSX2IP,
• Tight junction protein 1, and
• USP9X.

Further reading