| 2004 | Anchorman: The Legend of Ron Burgundy | Adam McKay | Will Ferrell and Adam McKay | Judd Apatow | DreamWorks Pictures | —N/a | $26 million | $90.5 million |
| 2005 | The 40-Year-Old Virgin | Judd Apatow | Judd Apatow and Steve Carell | Judd Apatow, Clayton Townsend and Shauna Robertson | Universal Pictures | $26 million | $177.3 million |
| 2006 | Talladega Nights: The Ballad of Ricky Bobby | Adam McKay | Will Ferrell and Adam McKay | Jimmy Miller and Judd Apatow | Columbia Pictures | Relativity Media and Mosaic Media Group | $72 million | $162.9 million |
| 2007 | Knocked Up | Judd Apatow | Judd Apatow, Shauna Robertson and Clayton Townsend | Universal Pictures | —N/a | $30 million | $219.1 million |
| Superbad | Greg Mottola | Seth Rogen and Evan Goldberg | Judd Apatow and Shauna Robertson | Columbia Pictures | $20 million | $169.9 million |
| Walk Hard: The Dewey Cox Story | Jake Kasdan | Judd Apatow and Jake Kasdan | Judd Apatow, Hunter Baumann and Clayton Townsend | Relativity Media | $35 million | $20.6 million |
| 2008 | Drillbit Taylor | Steven Brill | Kristofor Brown, John Hughes and Seth Rogen | Kristofor Brown and Seth Rogen | Judd Apatow, Susan Arnold and Donna Arkoff Roth | Paramount Pictures | Roth/Arnold Productions | $40 million | $49.7 million |
| Forgetting Sarah Marshall | Nicholas Stoller | Jason Segel | Judd Apatow, Shauna Robertson and Rodney Rothman | Universal Pictures | —N/a | $30 million | $105.2 million |
| Step Brothers | Adam McKay | Will Ferrell, Adam McKay, and John C. Reilly | Will Ferrell and Adam McKay | Jimmy Miller and Judd Apatow | Columbia Pictures | Relativity Media, Mosaic Media Group and Gary Sanchez Productions | $65 million | $128.1 million |
| Pineapple Express | David Gordon Green | Judd Apatow, Seth Rogen and Evan Goldberg | Seth Rogen and Evan Goldberg | Judd Apatow and Shauna Robertson | Relativity Media, Korty/Gordon Green Productions and Point Grey Pictures | $27 million | $101.6 million |
| 2009 | Year One | Harold Ramis | Harold Ramis, Gene Stupnitsky and Lee Eisenberg | Harold Ramis, Judd Apatow and Clayton Townsend | Ocean Pictures | $60 million | $62.4 million |
| Funny People | Judd Apatow | Judd Apatow, Clayton Townsend and Barry Mendel | Universal Pictures | Columbia Pictures, Relativity Media and Madison 23 Productions | $75 million | $71.6 million |
| 2010 | Get Him to the Greek | Nicholas Stoller | Judd Apatow, Nicholas Stoller, David Bushell and Rodney Rothman | Relativity Media and Spyglass Entertainment | $40 million | $91.3 million |
| 2011 | Bridesmaids | Paul Feig | Annie Mumolo and Kristen Wiig | Judd Apatow, Barry Mendel and Clayton Townsend | Relativity Media | $32 million | $288.4 million |
| 2012 | Wanderlust | David Wain | David Wain and Ken Marino | Judd Apatow, Ken Marino, Paul Rudd and David Wain | $32 million | $21.6 million |
| The Five-Year Engagement | Nicholas Stoller | Jason Segel and Nicholas Stoller | Judd Apatow, Nicholas Stoller and Rodney Rothman | $30 million | $53.9 million |
| This Is 40 | Judd Apatow | Judd Apatow, Barry Mendel and Clayton Townsend | —N/a | $35 million | $88.1 million |
| 2013 | Anchorman 2: The Legend Continues | Adam McKay | Will Ferrell and Adam McKay | Judd Apatow, Will Ferrell and Adam McKay | Paramount Pictures | Gary Sanchez Productions | $50 million | $173.6 million |
| 2014 | Begin Again | John Carney | Anthony Bregman, Tobin Armbrust and Judd Apatow | The Weinstein Company | Exclusive Media, Sycamore Pictures, Black Label Media and Likely Story | $8 million | $63.5 million |
| 2015 | Trainwreck | Judd Apatow | Amy Schumer | Judd Apatow and Barry Mendel | Universal Pictures | —N/a | $35 million | $113 million |
| 2016 | Pee-wee's Big Holiday | John Lee | Paul Reubens and Paul Rust | Judd Apatow and Paul Reubens | Netflix | Pee-wee Pictures | —N/a |
| Popstar: Never Stop Never Stopping | Akiva Schaffer and Jorma Taccone | Andy Samberg, Akiva Schaffer and Jorma Taccone | Judd Apatow, Rodney Rothman, Andy Samberg, Akiva Schaffer and Jorma Taccone | Universal Pictures | Perfect World Pictures and The Lonely Island | $20 million | $9.5 million |
| 2017 | The Big Sick | Michael Showalter | Emily V. Gordon and Kumail Nanjiani | Judd Apatow and Barry Mendel | Amazon Studios and Lionsgate | FilmNation Entertainment | $5 million | $53 million |
| 2018 | Juliet, Naked | Jesse Peretz | Tamara Jenkins, Jim Taylor, Phil Alden Robinson and Evgenia Peretz | Judd Apatow, Barry Mendel, Albert Berger, Ron Yerxa and Jeffrey Soros | Roadside Attractions and Lionsgate | Rocket Science, Bona Fide Productions and Los Angeles Media Fund | —N/a | $1.9 million |
| 2020 | The King of Staten Island | Judd Apatow | Judd Apatow, Pete Davidson and Dave Sirus | Judd Apatow and Barry Mendel | Universal Pictures | Perfect World Pictures | $35 million | $2.2 million |
| 2022 | The Bubble | Judd Apatow and Pam Brady | Judd Apatow | Netflix | —N/a |
| Bros | Nicholas Stoller | Nicholas Stoller and Billy Eichner | Judd Apatow, Nicholas Stoller and Joshua Church | Universal Pictures | Stoller Global Solutions | $22 million | $14.8 million |
| 2023 | Please Don't Destroy: The Treasure of Foggy Mountain | Paul Briganti | Martin Herlihy, John Higgins, Scott Sanders and Ben Marshall | Judd Apatow and Jimmy Miller | Universal Pictures and Peacock | Mosaic | —N/a |
| 2026 | Poetic License | Maude Apatow | Raffi Donatich | Judd Apatow, Maude Apatow, Josh Church, Thalia Daniel, Will Greenfield, Benjamin Hung and Olivia Rosenbloom | Sony Pictures Classics | August Night and Jewelbox Pictures | —N/a |
| 2027 | The Comeback King | Judd Apatow | Judd Apatow and Glen Powell | Judd Apatow, Glen Powell, Dan Cohen and Kevin Misher | Universal Pictures | Barnstorm Entertainment and Misher Films | —N/a |
| Average | $33,630,435 | $100,249,397 |