Apolipoprotein O

APOO

Identifiers

Aliases, FAM121B, MIC26, Mic23, My025, Apolipoprotein O, MICOS26

External IDsOMIM: ; MGI: ; HomoloGene: ; GeneCards: ; OMA:

Gene location ( Human )

Chr.X chromosome (human)

Band Xp22.11 Start 23,833,353 bp

End23,907,938 bp

Gene location ( Mouse )

Chr.X chromosome (mouse)

Band X|X C3 Start 93,410,723 bp

End93,460,699 bp

RNA expression patternHumanMouse (ortholog)decidua right ventricle myocardium of left ventricle prefrontal cortex pons olfactory zone of nasal mucosa lateral nuclear group of thalamus triceps brachii muscle Brodmann area 9 anterior cingulate cortexquadriceps femoris muscle right kidney muscle of thigh proximal tubule muscle tissue skeletal muscle tissue heart secondary oocyte primary oocyte zygoten/a

RNA expression pattern

HumanMouse (ortholog)decidua right ventricle myocardium of left ventricle prefrontal cortex pons olfactory zone of nasal mucosa lateral nuclear group of thalamus triceps brachii muscle Brodmann area 9 anterior cingulate cortexquadriceps femoris muscle right kidney muscle of thigh proximal tubule muscle tissue skeletal muscle tissue heart secondary oocyte primary oocyte zygote

Human Mouse (ortholog)

decidua right ventricle myocardium of left ventricle prefrontal cortex pons olfactory zone of nasal mucosa lateral nuclear group of thalamus triceps brachii muscle Brodmann area 9 anterior cingulate cortexquadriceps femoris muscle right kidney muscle of thigh proximal tubule muscle tissue skeletal muscle tissue heart secondary oocyte primary oocyte zygote

quadriceps femoris muscle right kidney muscle of thigh proximal tubule muscle tissue skeletal muscle tissue heart secondary oocyte primary oocyte zygote

n/a

Gene ontologyMolecular functionCellular componentBiological processSources: /

Gene ontology

Molecular function

Cellular component

Biological process

Sources: /

OrthologsSpeciesHumanMouseEntrez Ensembl UniProtRefSeq (mRNA)RefSeq (protein)Location (UCSC)PubMed search

Orthologs

Species Human Mouse

Entrez

Ensembl

UniProt

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

PubMed search

Wikidata

View/Edit HumanView/Edit Mouse

Apolipoprotein O also known as protein FAM121B is a protein that in humans is encoded by the APOO gene. APOO is a member of the apolipoprotein family.

The human, apolipoprotein O is a 198 amino acids protein that contains a 23 amino acids long signal peptide. The apoprotein is secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL. Apolipoprotein O is the first chondroitine sulphate chain containing apolipoprotein.

Apolipoproteins are proteins that binds to lipids. Members of this family promote cholesterol efflux from macrophage cells. They are present in various lipoprotein complexes, including HDL, LDL and VLDL.

External links

Human genome location and gene details page in the UCSC Genome Browser.

Apolipoprotein O

External links

Further reading