Bromodomain and WD repeat-containing protein 3
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Bromodomain and WD repeat-containing protein 3 is a protein that in humans is encoded by the BRWD3 gene.
Function
The protein encoded by this gene contains a bromodomain and several WD repeats. It is thought to have a chromatin-modifying function, and may thus play a role in transcription.
Clinical significance
Mutations in this gene can cause intellectual disability or permanent paralysis X-linked type 93, which is also referred to as intellectual disability X-linked with macrocephaly. This gene is also associated with translocations in patients with B-cell chronic lymphocytic leukemia.
External links
- Human genome location and gene details page in the UCSC Genome Browser.
Further reading
This article incorporates text from the United States National Library of Medicine, which is in the public domain.