Bay K8644

Names

Preferred IUPAC name Methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate

Identifiers

CAS NumberY

3D model (JSmol)

ChEBIN

ChEMBLN

ChemSpiderN

ECHA InfoCard

EC Number636-102-2

IUPHAR/BPS

PubChem CID

CompTox Dashboard (EPA)

InChI InChI=1S/C16H15F3N2O4/c1-8-12(15(22)25-3)13(14(21(23)24)9(2)20-8)10-6-4-5-7-11(10)16(17,18)19/h4-7,13,20H,1-3H3NKey: ZFLWDHHVRRZMEI-UHFFFAOYSA-NNInChI=1/C16H15F3N2O4/c1-8-12(15(22)25-3)13(14(21(23)24)9(2)20-8)10-6-4-5-7-11(10)16(17,18)19/h4-7,13,20H,1-3H3Key: ZFLWDHHVRRZMEI-UHFFFAOYAV

SMILES CC1=C(C(C(=C(N1)C)[N+](=O)[O-])C2=CC=CC=C2C(F)(F)F)C(=O)OC

Properties

Chemical formulaC16H15F3N2O4

Molar mass356.301 g·mol−1

Solubility in waterInsoluble

Solubility in other solventsDMSO: 184 mg/mL; methanol and ethanol: 63 mg/mL

Hazards

GHS labelling:

Pictograms

Signal wordWarning

Hazard statementsH315, H319

Precautionary statementsP264, P280, P302+P352, P305+P351+P338, P321, P332+P313, P337+P313, P362

Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is YN ?) Infobox references

Bay K8644 is a chemical compound that functions as an L-type calcium channel agonist. Bay K8644 is used primarily as a biochemical research tool for this effect. It is a structural analog of nifedipine with positive inotropic activity, and as an aromatic it is highly lipid soluble.

Mechanism of action

Bay K8644 targets L-type voltage-gated calcium channels. It is the first positive inotropic agent shown to act specifically and directly on calcium channels.