William Franklin Senn (July 14, 1905 – September 1973) was a professional American football running back in the National Football League. He played eight seasons for the Chicago Bears, the Brooklyn Dodgers, and the Cincinnati Reds/St. Louis Gunners.

Between 1935 and 1942 he operated a Canton creamery, and during the war served in the Army. In 1947 he became the football coach at Urbana High School.