Bone morphogenetic protein 3

BMP3

Identifiers

Aliases, BMP-3A, bone morphogenetic protein 3

External IDsOMIM: ; MGI: ; GeneCards:

Available structuresPDBOrtholog search:List of PDB id codes

Available structures

PDBOrtholog search:

List of PDB id codes

Gene location ( Human )

Chr.Chromosome 4 (human)

Band 4q21.21 Start 81,030,708 bp

End81,057,627 bp

Gene location ( Mouse )

Chr.Chromosome 5 (mouse)

Band 5 E3|5 48.24 cM Start 99,002,274 bp

End99,032,255 bp

RNA expression pattern

HumanMouse (ortholog)muscle layer of sigmoid colon testicle rectum transverse colon mucosa of transverse colon tibial nerve olfactory zone of nasal mucosa palpebral conjunctiva gallbladder epithelium of colonperichondrium lower lip upper lip urinary bladder nucleus pulposus cervical ganglion urethra skeleton facial skeleton ureter

Human Mouse (ortholog)

muscle layer of sigmoid colon testicle rectum transverse colon mucosa of transverse colon tibial nerve olfactory zone of nasal mucosa palpebral conjunctiva gallbladder epithelium of colonperichondrium lower lip upper lip urinary bladder nucleus pulposus cervical ganglion urethra skeleton facial skeleton ureter

muscle layer of sigmoid colon testicle rectum transverse colon mucosa of transverse colon tibial nerve olfactory zone of nasal mucosa palpebral conjunctiva gallbladder epithelium of colon

perichondrium lower lip upper lip urinary bladder nucleus pulposus cervical ganglion urethra skeleton facial skeleton ureter

Gene ontologyMolecular functionCellular componentBiological processSources: /

Gene ontology

Molecular function

Cellular component

Biological process

Sources: /

OrthologsDatabasesNCBI: ; OMA:SpeciesHumanMouseEntrez Ensembl UniProtRefSeq (mRNA)RefSeq (protein)Location (UCSC)PubMed search

Orthologs

DatabasesNCBI: ; OMA:

Species Human Mouse

Entrez

Ensembl

UniProt

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

PubMed search

Wikidata

View/Edit HumanView/Edit Mouse

Bone morphogenetic protein 3, also known as osteogenin, is a protein in humans that is encoded by the BMP3 gene.

The protein encoded by this gene is a member of the transforming growth factor beta superfamily. It, unlike other bone morphogenetic proteins (BMP's) inhibits the ability of other BMP's to induce bone and cartilage development. It is a disulfide-linked homodimer. It negatively regulates bone density. BMP3 is an antagonist to other BMP's in the differentiation of osteogenic progenitors. It is highly expressed in fractured tissues.

Cancer

BMP3 is hypermethylated in many cases of colorectal cancer (CRC) and hence along with other hypermethylated genes, may be used as a biomarker to detect early stage CRC.

External links

Humangenome location andgene details page in theUCSC Genome Browser.

Bone morphogenetic protein 3

Cancer

External links

Further reading