Protein chibby homolog 1

CBY1

Available structuresPDBOrtholog search:List of PDB id codes

Available structures

PDBOrtholog search:

List of PDB id codes

Identifiers

Aliases, C22orf2, CBY, HS508I15A, PGEA1, PIGEA-14, PIGEA14, arb1, chibby homolog 1 (Drosophila), chibby family member 1, beta catenin antagonist, Chibby1

External IDsOMIM: ; MGI: ; HomoloGene: ; GeneCards: ; OMA:

Gene location ( Human )

Chr.Chromosome 22 (human)

Band 22q13.1 Start 38,656,636 bp

End38,673,854 bp

Gene location ( Mouse )

Chr.Chromosome 15 (mouse)

Band 15 E1|15 Start 79,543,400 bp

End79,551,861 bp

RNA expression pattern

HumanMouse (ortholog)oocyte secondary oocyte right uterine tube tendon of biceps brachii epithelium of bronchus bronchial epithelial cell muscle layer of sigmoid colon apex of heart ventricular zone right auricle of heartspermatocyte interventricular septum ventricular zone medial ganglionic eminence seminiferous tubule neural tube dentate gyrus of hippocampal formation granule cell neural layer of retina visual cortex granulocyte

Human Mouse (ortholog)

oocyte secondary oocyte right uterine tube tendon of biceps brachii epithelium of bronchus bronchial epithelial cell muscle layer of sigmoid colon apex of heart ventricular zone right auricle of heartspermatocyte interventricular septum ventricular zone medial ganglionic eminence seminiferous tubule neural tube dentate gyrus of hippocampal formation granule cell neural layer of retina visual cortex granulocyte

spermatocyte interventricular septum ventricular zone medial ganglionic eminence seminiferous tubule neural tube dentate gyrus of hippocampal formation granule cell neural layer of retina visual cortex granulocyte

Gene ontologyMolecular functionCellular componentBiological processSources: /

Gene ontology

Molecular function

Cellular component

Biological process

Sources: /

OrthologsSpeciesHumanMouseEntrez Ensembl UniProtRefSeq (mRNA)RefSeq (protein)Location (UCSC)PubMed search

Orthologs

Species Human Mouse

Entrez

Ensembl

UniProt

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

PubMed search

Wikidata

View/Edit HumanView/Edit Mouse

Protein chibby homolog 1 is a protein that in humans is encoded by the CBY1 gene.

Function

Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers. The protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to beta-catenin. Two transcript variants encoding different isoforms have been found for this gene.

Interactions

CBY1 has been shown to interact with Beta-catenin. CBY1 has also been shown to interact with CEP164, CIBAR1 (FAM92A1), and RAB8A.

External links

Human genome location and gene details page in the UCSC Genome Browser.

Protein chibby homolog 1

Function

Interactions

External links

Further reading