Integrin alpha 5

ITGA5

Available structuresPDBOrtholog search:List of PDB id codes, , , , ,

Available structures

PDBOrtholog search:

List of PDB id codes, , , , ,

List of PDB id codes

, , , , ,

Identifiers

Aliases, CD49e, FNRA, VLA5A, VLA-5, integrin subunit alpha 5

External IDsOMIM: ; MGI: ; HomoloGene: ; GeneCards: ; OMA:

Gene location ( Human )

Chr.Chromosome 12 (human)

Band 12q13.13 Start 54,395,261 bp

End54,419,266 bp

Gene location ( Mouse )

Chr.Chromosome 15 (mouse)

Band 15 F3|15 58.9 cM Start 103,252,713 bp

End103,275,190 bp

RNA expression pattern

HumanMouse (ortholog)tibial arteries saphenous vein muscle layer of sigmoid colon Descending thoracic aorta stromal cell of endometrium ascending aorta smooth muscle tissue left uterine tube upper lobe of left lung right lungtail of embryo decidua ascending aorta aortic valve gastrula stroma of bone marrow yolk sac genital tubercle atrium urinary bladder

Human Mouse (ortholog)

tibial arteries saphenous vein muscle layer of sigmoid colon Descending thoracic aorta stromal cell of endometrium ascending aorta smooth muscle tissue left uterine tube upper lobe of left lung right lungtail of embryo decidua ascending aorta aortic valve gastrula stroma of bone marrow yolk sac genital tubercle atrium urinary bladder

tail of embryo decidua ascending aorta aortic valve gastrula stroma of bone marrow yolk sac genital tubercle atrium urinary bladder

Gene ontologyMolecular functionCellular componentBiological processSources: /

Gene ontology

Molecular function

Cellular component

Biological process

Sources: /

OrthologsSpeciesHumanMouseEntrez Ensembl UniProtRefSeq (mRNA)RefSeq (protein)Location (UCSC)PubMed search

Orthologs

Species Human Mouse

Entrez

Ensembl

UniProt

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

PubMed search

Wikidata

View/Edit HumanView/Edit Mouse

Integrin alpha-5 is a protein that in humans is encoded by the ITGA5 gene.

The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.

Interactions

ITGA5 has been shown to interact with GIPC1.

External links

at the U.S. National Library of MedicineMedical Subject Headings(MeSH)
Info with links in the 2014-12-11 at theWayback Machine
Overview of all the structural information available in thePDBforUniProt:(Human Integrin alpha-5) at thePDBe-KB.

Integrin alpha 5

Interactions

See also

Further reading

External links