CD79b molecule, immunoglobulin-associated beta, also known as CD79B (Cluster of Differentiation 79B), is a human gene.

It is associated with agammaglobulinemia-6.

The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described.

See also

Further reading

  • Reth M (1992). "Antigen receptors on B lymphocytes". Annu. Rev. Immunol. 10: 97–121. doi:. PMID .
  • Müller B, Cooper L, Terhorst C (1992). "Cloning and sequencing of the cDNA encoding the human homologue of the murine immunoglobulin-associated protein B29". Eur. J. Immunol. 22 (6): 1621–5. doi:. PMID . S2CID .
  • Lankester AC, van Schijndel GM, Cordell JL, et al. (1994). "CD5 is associated with the human B cell antigen receptor complex". Eur. J. Immunol. 24 (4): 812–6. doi:. PMID . S2CID .
  • Vasile S, Coligan JE, Yoshida M, Seon BK (1994). "Isolation and chemical characterization of the human B29 and mb-1 proteins of the B cell antigen receptor complex". Mol. Immunol. 31 (6): 419–27. doi:. PMID .
  • Brown VK, Ogle EW, Burkhardt AL, et al. (1994). . J. Biol. Chem. 269 (25): 17238–44. doi:. PMID .
  • Rowley RB, Burkhardt AL, Chao HG, et al. (1995). . J. Biol. Chem. 270 (19): 11590–4. doi:. PMID .
  • Pani G, Kozlowski M, Cambier JC, et al. (1995). . J. Exp. Med. 181 (6): 2077–84. doi:. PMC . PMID .
  • Müller B, Cooper L, Terhorst C (1995). "Interplay between the human TCR/CD3 epsilon and the B-cell antigen receptor associated Ig-beta (B29)". Immunol. Lett. 44 (2–3): 97–103. doi:. PMID .
  • Saouaf SJ, Kut SA, Fargnoli J, et al. (1995). . J. Biol. Chem. 270 (45): 27072–8. doi:. PMID .
  • Hashimoto S, Chiorazzi N, Gregersen PK (1995). . Mol. Immunol. 32 (9): 651–9. doi:. PMID .
  • Hashimoto S, Chiorazzi N, Gregersen PK (1994). "The complete sequence of the human CD79b (Ig beta/B29) gene: identification of a conserved exon/intron organization, immunoglobulin-like regulatory regions, and allelic polymorphism". Immunogenetics. 40 (2): 145–9. doi:. PMID . S2CID .
  • Gold MR, Chiu R, Ingham RJ, et al. (1994). "Activation and serine phosphorylation of the p56lck protein tyrosine kinase in response to antigen receptor cross-linking in B lymphocytes". J. Immunol. 153 (6): 2369–80. doi:. PMID . S2CID .
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:. PMID .
  • Hashimoto S, Gregersen PK, Chiorazzi N (1993). . J. Immunol. 150 (2): 491–8. doi:. PMID . S2CID .
  • Wood WJ, Thompson AA, Korenberg J, et al. (1993). "Isolation and chromosomal mapping of the human immunoglobulin-associated B29 gene (IGB)". Genomics. 16 (1): 187–92. doi:. PMID .
  • Thompson AA, Wood WJ, Gilly MJ, et al. (1996). . Blood. 87 (2): 666–73. doi:. PMID .
  • Astsaturov IA, Matutes E, Morilla R, et al. (1996). "Differential expression of B29 (CD79b) and mb-1 (CD79a) proteins in acute lymphoblastic leukaemia". Leukemia. 10 (5): 769–73. PMID .
  • Koyama M, Nakamura T, Higashihara M, et al. (1996). "The novel variants of mb-1 and B29 transcripts generated by alternative mRNA splicing". Immunol. Lett. 47 (3): 151–6. doi:. PMID .
  • Carter RH, Doody GM, Bolen JB, Fearon DT (1997). . J. Immunol. 158 (7): 3062–9. doi:. PMID . S2CID .

External links

  • at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
  • Human genome location and gene details page in the UCSC Genome Browser.
  • provides an overview of all the structure information available in the PDB for Human B-cell antigen receptor complex-associated protein beta chain (CD79B)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.