CHAF1B

Identifiers

Aliases, CAF-1, CAF-IP60, CAF1, CAF1A, CAF1P60, MPHOSPH7, MPP7, chromatin assembly factor 1 subunit B

External IDsOMIM: ; MGI: ; HomoloGene: ; GeneCards: ; OMA:

Gene location ( Human )

Chr.Chromosome 21 (human)

Band 21q22.12-q22.13 Start 36,385,392 bp

End36,419,015 bp

Gene location ( Mouse )

Chr.Chromosome 16 (mouse)

Band 16 C4|16 54.96 cM Start 93,680,789 bp

End93,703,003 bp

RNA expression pattern

HumanMouse (ortholog)secondary oocyte gastrocnemius muscle muscle of thigh ventricular zone ganglionic eminence buccal mucosa cell testicle stromal cell of endometrium gonad skeletal muscle tissueembryo epiblast genital tubercle primitive streak tail of embryo embryo abdominal wall ventricular zone morula yolk sac

Human Mouse (ortholog)

secondary oocyte gastrocnemius muscle muscle of thigh ventricular zone ganglionic eminence buccal mucosa cell testicle stromal cell of endometrium gonad skeletal muscle tissueembryo epiblast genital tubercle primitive streak tail of embryo embryo abdominal wall ventricular zone morula yolk sac

secondary oocyte gastrocnemius muscle muscle of thigh ventricular zone ganglionic eminence buccal mucosa cell testicle stromal cell of endometrium gonad skeletal muscle tissue

embryo epiblast genital tubercle primitive streak tail of embryo embryo abdominal wall ventricular zone morula yolk sac

Gene ontologyMolecular functionCellular componentBiological processSources: /

Gene ontology

Molecular function

Cellular component

Biological process

Sources: /

OrthologsSpeciesHumanMouseEntrez Ensembl UniProtRefSeq (mRNA)RefSeq (protein)Location (UCSC)PubMed search

Orthologs

Species Human Mouse

Entrez

Ensembl

UniProt

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

PubMed search

Wikidata

View/Edit HumanView/Edit Mouse

Chromatin assembly factor 1 subunit B is a protein that in humans is encoded by the CHAF1B gene.

Function

Chromatin assembly factor I (CAF-1) is required for the assembly of histone octamers onto newly-replicated DNA. CAF-I is composed of three protein subunits, p50, p60, and p150. The protein encoded by this gene corresponds to the p60 subunit and is required for chromatin assembly after replication. The encoded protein is differentially phosphorylated in a cell cycle-dependent manner. In addition, it is normally found in the nucleus except during mitosis, when it is released into the cytoplasm. This protein is a member of the WD-repeat HIR1 family and may also be involved in DNA repair.

Interactions

CHAF1B has been shown to interact with:

External links

Human genome location and gene details page in the UCSC Genome Browser.
Human genome location and gene details page in the UCSC Genome Browser.

CHAF1B

Function

Interactions

Further reading

External links