CIZ1

Identifiers

Aliases, LSFR1, NP94, ZNF356, CDKN1A interacting zinc finger protein 1

External IDsOMIM: ; MGI: ; HomoloGene: ; GeneCards: ; OMA:

Gene location ( Human )

Chr.Chromosome 9 (human)

Band 9q34.11 Start 128,161,251 bp

End128,204,383 bp

Gene location ( Mouse )

Chr.Chromosome 2 (mouse)

Band 2|2 B Start 32,242,339 bp

End32,270,982 bp

RNA expression pattern

HumanMouse (ortholog)right hemisphere of cerebellum left ovary right ovary tibial nerve canal of the cervix body of pancreas skin of leg body of uterus skin of abdomen muscle layer of sigmoid colongenital tubercle neural layer of retina tail of embryo aortic valve yolk sac primary visual cortex ascending aorta ventricular zone muscle of thigh granulocyte

Human Mouse (ortholog)

right hemisphere of cerebellum left ovary right ovary tibial nerve canal of the cervix body of pancreas skin of leg body of uterus skin of abdomen muscle layer of sigmoid colongenital tubercle neural layer of retina tail of embryo aortic valve yolk sac primary visual cortex ascending aorta ventricular zone muscle of thigh granulocyte

right hemisphere of cerebellum left ovary right ovary tibial nerve canal of the cervix body of pancreas skin of leg body of uterus skin of abdomen muscle layer of sigmoid colon

genital tubercle neural layer of retina tail of embryo aortic valve yolk sac primary visual cortex ascending aorta ventricular zone muscle of thigh granulocyte

OrthologsSpeciesHumanMouseEntrez Ensembl UniProtn/aRefSeq (mRNA)RefSeq (protein)n/aLocation (UCSC)PubMed search

Orthologs

Species Human Mouse

Entrez

Ensembl

UniProt n/a

n/a

RefSeq (mRNA)

RefSeq (protein) n/a

n/a

Location (UCSC)

PubMed search

Wikidata

View/Edit HumanView/Edit Mouse

Cip1-interacting zinc finger protein is a protein that in humans is encoded by the CIZ1 gene.

Function

The protein encoded by this gene is a zinc finger DNA binding transcription factor that interacts with CIP1 (p21 / CDKN1A), part of a complex with cyclin E. The encoded protein may regulate the cellular localization of CIP1.

Clinical significance

An altered circulating form of the Ciz1 protein is synthesized by lung cancer cells, even when they are at a very early stage. Hence detection of this protein variant in blood could be used as a biomarker for early detection of lung cancer.

Ciz1 mutant mice

Aged (18-mo-old) Ciz1-/- mice have increased neuronal DNA double-strand breaks that likely contributed to their loss of neurons and cognitive decline with age. Embryonic fibroblasts from Ciz1-/- mice show abnormal sensitivity to γ-irradiation with persistent DNA breaks, aberrant cell cycle progression and increased apoptosis.

Interactions

CIZ1 has been shown to interact with P21.

External links

Human genome location and gene details page in the UCSC Genome Browser.