CRKL

Crk-like protein is a protein that in humans is encoded by the CRKL gene.

Function

v-CRK avian sarcoma virus CT10-homolog-like contains one SH2 domain and two SH3 domains. CRKL has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase and plays a role in fibroblast transformation by BCR-ABL. In addition, CRKL has oncogenic potential.

CrkL together with Crk participates in the Reelin signaling cascade downstream of DAB1.

Interactions

CRKL has been shown to interact with:

• Abl gene,
• BCAR1,
• BCR gene,
• CBLB,
• CD117,
• CD34,
• Cbl gene,
• Dock2,
• EPOR,
• GAB1,
• GAB2,
• INPP5D,
• MAP4K1,
• MAP4K5,
• NEDD9,
• PIK3R2,
• Paxillin
• RAPGEF1,
• RICS,
• STAT5A,
• Syk, and
• WAS.

See also

• Crk

Further reading

External links

• Human genome location and gene details page in the UCSC Genome Browser.