Prolycopene isomerase (EC , CRTISO, carotene cis-trans isomerase, ZEBRA2 (gene), carotene isomerase, carotenoid isomerase) is an enzyme with systematic name 7,9,7',9'-tetracis-lycopene cis-trans-isomerase. This enzyme catalyses the following chemical reaction

7,9,7',9'-tetracis-lycopene ⇌ {\displaystyle \rightleftharpoons } all-trans-lycopene

This enzyme is involved in carotenoid biosynthesis.

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