Pope Pius V (1504–72).

Pope Pius V (r. 1566–1572) created 21 cardinals in three consistories.

6 March 1566

  1. Michele Bonelli

24 March 1568

  1. Diego de Espinosa
  2. Jérôme Souchier
  3. Gianpaolo Della Chiesa
  4. Antonio Carafa

17 May 1570

Paolo Burali d'Arezzo (1511–78), made a cardinal on May 17, 1570.
  1. Marcantonio Maffei
  2. Gaspar Cervantes de Gaeta
  3. Giulio Antonio Santorio
  4. Pier Donato Cesi
  5. Carlo Grassi
  6. Charles d'Angennes de Rambouillet
  7. Felice Peretti di Montalto (future Pope Sixtus V, from 1585 to 1590.)
  8. Giovanni Aldobrandini
  9. Girolamo Rusticucci
  10. Giulio Acquaviva d'Aragona
  11. Gaspar de Zúñiga y Avellaneda
  12. Nicolas de Pellevé
  13. Archangelo de' Bianchi
  14. Paolo Burali d'Arezzo
  15. Vincenzo Giustiniani
  16. Gian Girolamo Albani