Cardiotrophin 1

CTF1

Identifiers

Aliases, cardiotrophin 1, CT-1, CT1

External IDsOMIM: ; MGI: ; HomoloGene: ; GeneCards: ; OMA:

Gene location ( Human )

Chr.Chromosome 16 (human)

Band 16p11.2 Start 30,896,614 bp

End30,903,547 bp

Gene location ( Mouse )

Chr.Chromosome 7 (mouse)

Band 7|7 F3 Start 127,311,908 bp

End127,317,364 bp

RNA expression patternHumanMouse (ortholog)apex of heart muscle of thigh body of uterus popliteal artery tibial arteries left ovary right auricle of heart right ovary left ventricle canal of the cervixvestibular membrane of cochlear duct Epithelium of choroid plexus retinal pigment epithelium epithelium of lens ciliary body vestibular sensory epithelium muscle of thigh choroid plexus of fourth ventricle internal carotid artery external carotid arteryn/a

RNA expression pattern

HumanMouse (ortholog)apex of heart muscle of thigh body of uterus popliteal artery tibial arteries left ovary right auricle of heart right ovary left ventricle canal of the cervixvestibular membrane of cochlear duct Epithelium of choroid plexus retinal pigment epithelium epithelium of lens ciliary body vestibular sensory epithelium muscle of thigh choroid plexus of fourth ventricle internal carotid artery external carotid artery

Human Mouse (ortholog)

apex of heart muscle of thigh body of uterus popliteal artery tibial arteries left ovary right auricle of heart right ovary left ventricle canal of the cervixvestibular membrane of cochlear duct Epithelium of choroid plexus retinal pigment epithelium epithelium of lens ciliary body vestibular sensory epithelium muscle of thigh choroid plexus of fourth ventricle internal carotid artery external carotid artery

apex of heart muscle of thigh body of uterus popliteal artery tibial arteries left ovary right auricle of heart right ovary left ventricle canal of the cervix

vestibular membrane of cochlear duct Epithelium of choroid plexus retinal pigment epithelium epithelium of lens ciliary body vestibular sensory epithelium muscle of thigh choroid plexus of fourth ventricle internal carotid artery external carotid artery

n/a

Gene ontologyMolecular functionCellular componentBiological processSources: /

Gene ontology

Molecular function

Cellular component

Biological process

Sources: /

OrthologsSpeciesHumanMouseEntrez Ensembl UniProtRefSeq (mRNA)RefSeq (protein)Location (UCSC)PubMed search

Orthologs

Species Human Mouse

Entrez

Ensembl

UniProt

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

PubMed search

Wikidata

View/Edit HumanView/Edit Mouse

Cardiotrophin-1 (CT-1) is a protein encoded by the CTF1 gene in humans. It functions as a cytokine and acts as a 21.5 kDa cardiac hypertrophic factor. CT-1 belongs to the IL-6 cytokine family.

Tissue distribution

CT-1 is highly expressed in the heart, skeletal muscle, prostate and ovary and to lower levels in lung, kidney, pancreas, thymus, testis and small intestine.

Mode of action

The protein exerts its cellular effects by interacting with the glycoprotein 130 (gp130)/leukemia inhibitory factor receptor beta (LIFR) heterodimer. In addition, CT-1 activates phosphatidylinositol 3-kinase (PI-3 kinase) in cardiac myocytes and enhances transcription factor NF-κB DNA -binding activities.

Clinical significance

CT-1 is associated with the pathophysiology of heart diseases, including hypertension, myocardial infarction, valvular heart disease, and congestive heart failure.

Exogenous administration of CT-1 in rodents has been found to mimic the beneficial effects of exercise on the heart in a rodent model of severe right-sided heart failure.

CT-1 is under formal development for the treatment of reperfusion injury. It is or was also under development for treatment of acute kidney injury, diabetes mellitus, ischemia, liver failure, and obesity, but no recent development for these indications has been reported.

External links