A chloride channel blocker is a type of drug which inhibits the transmission of ions (Cl−) through chloride channels.

Niflumic acid is a chloride channel blocker that has been used in experimental scientific research. Another example is anthracene-9-carboxylic acid, a potent blocker of the CLCN1-type chloride channel found in skeletal muscle, which is used to study animal models of myotonia congenita.

Some antagonists of glycine receptors and GABAA receptors also act as chloride channel blockers.

See also

Further reading

  • Phillis JW, Song D, O'Regan MH (January 1998). "Tamoxifen, a chloride channel blocker, reduces glutamate and aspartate release from the ischemic cerebral cortex". Brain Research. 780 (2): 352–5. doi:. PMID . S2CID .
  • Zhou, Yuhong; Shapiro, Michael; Dong, Qu; Louahed, Jamila; Weiss, Christine; Wan, Shanhong; Chen, Qiming; Dragwa, Carl; Savio, Dawn; Huang, Minxue; Fuller, Catherine; Tomer, Yaniv; Nicolaides, Nicholas C.; McLane, Michael; Levitt, Roy C. (2002). . Mucus Hypersecretion in Respiratory Disease. Novartis Foundation Symposia. Vol. 248. pp. 150–170. doi:. ISBN 9780470844786.
  • Mohamed F, Senarathna L, Percy A, Abeyewardene M, Eaglesham G, Cheng R, Azher S, Hittarage A, Dissanayake W, Sheriff MH, Davies W, Buckley NA, Eddleston M (2004). . Journal of Toxicology. Clinical Toxicology. 42 (7): 955–63. doi:. PMC . PMID .
  • Lukacs GL, Nanda A, Rotstein OD, Grinstein S (August 1991). . FEBS Letters. 288 (1–2): 17–20. Bibcode:. doi:. PMID . S2CID .
  • Kang JX, Man SF, Brown NE, Labrecque PA, Clandinin MT (August 1992). . The Biochemical Journal. 285 ( Pt 3) (3): 725–9. doi:. PMC . PMID .
  • Liu J, Lai ZF, Wang XD, Tokutomi N, Nishi K (April 1998). . Journal of Cardiovascular Pharmacology. 31 (4): 558–67. doi:. PMID .