In enzymology, a codeinone reductase (NADPH) (EC ) is an enzyme that catalyzes the chemical reaction

codeine + NADP+ ⇌ {\displaystyle \rightleftharpoons } codeinone + NADPH + H+

Thus, the two substrates of this enzyme are codeine and NADP+, whereas its 3 products are codeinone, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is codeine:NADP+ oxidoreductase. This enzyme participates in alkaloid biosynthesis i.

  • Lenz R; Zenk MH (1995). "Stereoselective reduction of codeinone, the penultimate step during morphine biosynthesis in Papaver somniferum". Tetrahedron Lett. 36 (14): 2449–2452. doi:.
  • Lenz R, Zenk MH (1995). . Eur. J. Biochem. 233 (1): 132–9. doi:. PMID .