DUSP16

Available structuresPDBHuman UniProt search:List of PDB id codes, ,

Available structures

PDBHuman UniProt search:

List of PDB id codes, ,

List of PDB id codes

, ,

Identifiers

Aliases, MKP-7, MKP7, dual specificity phosphatase 16

External IDsOMIM: ; MGI: ; HomoloGene: ; GeneCards: ; OMA:

Gene location ( Human )

Chr.Chromosome 12 (human)

Band 12p13.2 Start 12,473,282 bp

End12,562,863 bp

Gene location ( Mouse )

Chr.Chromosome 6 (mouse)

Band 6 G1|6 65.77 cM Start 134,692,431 bp

End134,769,588 bp

RNA expression patternHumanMouse (ortholog)corpus callosum ventricular zone tonsil right adrenal cortex left adrenal gland left adrenal cortex liver islet of Langerhans duodenum epithelium of colonsaccule transitional epithelium of urinary bladder otic placode otic vesicle conjunctival fornix vestibular membrane of cochlear duct lacrimal gland right lung lobe epidermis hair folliclen/a

RNA expression pattern

HumanMouse (ortholog)corpus callosum ventricular zone tonsil right adrenal cortex left adrenal gland left adrenal cortex liver islet of Langerhans duodenum epithelium of colonsaccule transitional epithelium of urinary bladder otic placode otic vesicle conjunctival fornix vestibular membrane of cochlear duct lacrimal gland right lung lobe epidermis hair follicle

Human Mouse (ortholog)

corpus callosum ventricular zone tonsil right adrenal cortex left adrenal gland left adrenal cortex liver islet of Langerhans duodenum epithelium of colonsaccule transitional epithelium of urinary bladder otic placode otic vesicle conjunctival fornix vestibular membrane of cochlear duct lacrimal gland right lung lobe epidermis hair follicle

corpus callosum ventricular zone tonsil right adrenal cortex left adrenal gland left adrenal cortex liver islet of Langerhans duodenum epithelium of colon

saccule transitional epithelium of urinary bladder otic placode otic vesicle conjunctival fornix vestibular membrane of cochlear duct lacrimal gland right lung lobe epidermis hair follicle

n/a

Gene ontologyMolecular functionCellular componentBiological processSources: /

Gene ontology

Molecular function

Cellular component

Biological process

Sources: /

OrthologsSpeciesHumanMouseEntrez Ensembl UniProtn/aRefSeq (mRNA)RefSeq (protein)n/aLocation (UCSC)PubMed search

Orthologs

Species Human Mouse

Entrez

Ensembl

UniProt n/a

n/a

RefSeq (mRNA)

RefSeq (protein) n/a

n/a

Location (UCSC)

PubMed search

Wikidata

View/Edit HumanView/Edit Mouse

Dual specificity protein phosphatase 16 is an enzyme that in humans is encoded by the DUSP16 gene.

The activation of mitogen-activated protein kinase (MAPK) cascades transduces various extracellular signals to the nucleus to induce gene expression, cell proliferation, differentiation, cell cycle arrest, and apoptosis. For full activation of MAPKs, dual-specificity kinases phosphorylate both threonine and tyrosine residues in MAPK TXY motifs. MKPs are dual-specificity phosphatases that dephosphorylate the TXY motif, thereby negatively regulating MAPK activity.[supplied by OMIM]

Interactions

DUSP16 has been shown to interact with MAPK14 and MAPK8IP1.

External links

provides an overview of all the structure information available in the PDB for Human Dual specificity protein phosphatase 16

DUSP16

Interactions

Further reading

External links