Dual specificity phosphatase 6 (DUSP6) is a phosphatase enzyme that is encoded by the DUSP6 gene in humans.

Function

DUSP6 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation.

DUSP6 inactivates ERK2 and is expressed in a variety of tissues with the highest levels in heart and pancreas and, unlike most other members of this family, is localized in the cytoplasm.

Two transcript variants encoding different isoforms have been found for this gene.

Interactions

DUSP6 has been shown to interact with MAPK3.

Further reading

External links

  • Overview of all the structural information available in the PDB for UniProt: (Dual specificity protein phosphatase 6) at the PDBe-KB.