EPHA8

Available structuresPDBOrtholog search:List of PDB id codes, ,

Available structures

PDBOrtholog search:

List of PDB id codes, ,

List of PDB id codes

, ,

Identifiers

Aliases, EEK, EK3, HEK3, EPH receptor A8

External IDsOMIM: ; MGI: ; HomoloGene: ; GeneCards: ; OMA:

Gene location ( Human )

Chr.Chromosome 1 (human)

Band 1p36.12 Start 22,563,489 bp

End22,603,595 bp

Gene location ( Mouse )

Chr.Chromosome 4 (mouse)

Band 4|4 D3 Start 136,929,419 bp

End136,956,816 bp

RNA expression patternHumanMouse (ortholog)endothelial cell gonad spleen hypothalamus secondary oocyte mesencephalon substantia nigra prefrontal cortex cingulate gyrus anterior cingulate cortexneural layer of retina cerebellar cortex Ileal epithelium perirhinal cortex visual cortex superior frontal gyrus lacrimal groove primary visual cortex entorhinal cortex lensn/a

RNA expression pattern

HumanMouse (ortholog)endothelial cell gonad spleen hypothalamus secondary oocyte mesencephalon substantia nigra prefrontal cortex cingulate gyrus anterior cingulate cortexneural layer of retina cerebellar cortex Ileal epithelium perirhinal cortex visual cortex superior frontal gyrus lacrimal groove primary visual cortex entorhinal cortex lens

Human Mouse (ortholog)

endothelial cell gonad spleen hypothalamus secondary oocyte mesencephalon substantia nigra prefrontal cortex cingulate gyrus anterior cingulate cortexneural layer of retina cerebellar cortex Ileal epithelium perirhinal cortex visual cortex superior frontal gyrus lacrimal groove primary visual cortex entorhinal cortex lens

endothelial cell gonad spleen hypothalamus secondary oocyte mesencephalon substantia nigra prefrontal cortex cingulate gyrus anterior cingulate cortex

neural layer of retina cerebellar cortex Ileal epithelium perirhinal cortex visual cortex superior frontal gyrus lacrimal groove primary visual cortex entorhinal cortex lens

n/a

Gene ontologyMolecular functionreceptor tyrosine kinaseCellular componentBiological processSources: /

Gene ontology

Molecular functionreceptor tyrosine kinase

Cellular component

Biological process

Sources: /

OrthologsSpeciesHumanMouseEntrez Ensembl UniProtRefSeq (mRNA)RefSeq (protein)Location (UCSC)PubMed search

Orthologs

Species Human Mouse

Entrez

Ensembl

UniProt

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

PubMed search

Wikidata

View/Edit HumanView/Edit Mouse

Ephrin type-A receptor 8 is a protein that in humans is encoded by the EPHA8 gene.

Function

This gene encodes a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. The protein encoded by this gene functions as a receptor for ephrin A2, A3 and A5 and plays a role in short-range contact-mediated axonal guidance during development of the mammalian nervous system.

Interactions

EPHA8 has been shown to interact with FYN.

EPHA8

Function

Interactions

Further reading