ETS2

ETS2 is a gene that in humans is encoding the C-ETS2 protein. The protein encoded by this gene belongs to the ETS family of transcription factors. It has been found to play a key role in the development of inflammatory bowel disease.

Interactions

ETS2 has been shown to interact with:

• C-jun,
• Cyclin-dependent kinase 10,
• ERG,
• myb, and
• ZMYND11.

Clinical significance

ETS2 has been linked to a variety of diseases, including Takayasu's arteritis, inflammatory bowel disease, primary sclerosing cholangitis, and ankylosing spondylitis, all associated with a region on chromosome 21 at 21q22.

Further reading

External links