FRS2

Available structuresPDBOrtholog search:List of PDB id codes,

Available structures

PDBOrtholog search:

List of PDB id codes,

List of PDB id codes

Identifiers

Aliases, FRS2A, FRS2alpha, SNT, SNT-1, SNT1, FRS1A, fibroblast growth factor receptor substrate 2

External IDsOMIM: ; MGI: ; HomoloGene: ; GeneCards: ; OMA:

Gene location ( Human )

Chr.Chromosome 12 (human)

Band 12q15 Start 69,470,349 bp

End69,579,793 bp

RNA expression pattern

HumanMouse (ortholog)Achilles tendon endothelial cell ventricular zone testicle epithelium of colon gonad ganglionic eminence islet of Langerhans stromal cell of endometrium C1 segmentn/a

Human Mouse (ortholog)

Achilles tendon endothelial cell ventricular zone testicle epithelium of colon gonad ganglionic eminence islet of Langerhans stromal cell of endometrium C1 segmentn/a

Achilles tendon endothelial cell ventricular zone testicle epithelium of colon gonad ganglionic eminence islet of Langerhans stromal cell of endometrium C1 segment

n/a

Gene ontologyMolecular functionCellular componentBiological processSources: /

Gene ontology

Molecular function

Cellular component

Biological process

Sources: /

OrthologsSpeciesHumanMouseEntrez Ensembl UniProtRefSeq (mRNA)RefSeq (protein)Location (UCSC)n/aPubMed search

Orthologs

Species Human Mouse

Entrez

Ensembl

UniProt

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC) n/a

PubMed search

Wikidata

View/Edit HumanView/Edit Mouse

Fibroblast growth factor receptor substrate 2 is a protein that in humans is encoded by the FRS2 gene.

FRS2 is an 80 kDa membrane-anchored signal transducing adaptor protein (STAP) that links specific activated Receptor Tyrosine Kinases (RTKs) to multiple downstream signaling pathways, most notably the MAPK/ERK, PI3K/AKT/mTOR and PLCγ pathways. It is overexpressed and amplified in several cancer types, including prostate cancer.

Interactions

FRS2 has been shown to interact with:

FRS2

Interactions

Further reading