Ferroxidase

Ferroxidase also known as Fe(II):oxygen oxidoreductase is an enzyme that catalyzes the oxidization of iron II to iron III:

4 Fe2+ + 4 H+ + O2 ⇔ 4 Fe3+ + 2H2O

Examples

Human genes encoding proteins with ferroxidase activity include:

• CP – Ceruloplasmin
• FTH1 – Ferritin heavy chain
• FTMT – Ferritin, mitochondrial
• HEPH - Hephaestin

• Cox JC, Boxer DH (1986). "The role of rusticyanin, a blue copper protein, in the electron transport chain of Thiobacillus ferrooxidans grown on iron or thiosulfate". Biotechnol. Appl. Biochem. 8: 269–275.
• Osaki S (November 1966). . J. Biol. Chem. 241 (21): 5053–9. doi:. PMID .
• Osaki S, Walaas O (June 1967). . J. Biol. Chem. 242 (11): 2653–7. doi:. PMID .