Gamma-glutamyl hydrolase
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Gamma-glutamyl hydrolase is an enzyme that catalyses the following chemical reaction:
Hydrolysis of a gamma-glutamyl bond
This lysosomal or secreted, thiol-dependent peptidase, most active at acidic pH.
In humans, gamma-glutamyl hydrolase is encoded by the GGH gene. This gene catalyzes the hydrolysis of folylpoly-gamma-glutamates and antifolylpoly-gamma-glutamates by the removal of gamma-linked polyglutamates and glutamate.
Nomenclature
Gamma-glutamyl hydrolase is also known as conjugase, folate conjugase, lysosomal gamma-glutamyl carboxypeptidase, gamma-Glu-X carboxypeptidase, pteroyl-poly-gamma-glutamate hydrolase, carboxypeptidase G, folic acid conjugase, poly(gamma-glutamic acid) endohydrolase, polyglutamate hydrolase, poly(glutamic acid) hydrolase II, pteroylpoly-gamma-glutamyl hydrolase.
Interactive pathway map
Click on genes, proteins and metabolites below to link to respective articles.
Further reading
External links
- at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- Overview of all the structural information available in the PDB for UniProt: (Gamma-glutamyl hydrolase) at the PDBe-KB.