GFRα

The GDNF family receptor-α (GFRα) proteins are a group of co-receptors which form complexes with GDNF-family ligands (GFLs) to activate RET, the receptor of the GFLs. The GFRα co-receptors include the following:

• GFRα1 – preference for GDNF
• GFRα2 – preference for neurturin
• GFRα3 – preference for artemin
• GFRα4 – preference for persephin
• GFRAL - receptor for GDF15