Protein wntless homolog, commonly known as Wntless, is encoded in humans by the WLS gene. Wntless is a receptor for Wnt proteins in Wnt-secreting cells.

Wntless was shown to be a cargo for the retromer complex. It has been found essential for hair follicle induction.

A homozygous missense mutation in the WLS gene was identified in Zaki syndrome.

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.