G protein-coupled receptor 6, also known as GPR6, is a protein which in humans is encoded by the GPR6 gene.

Function

GPR6 is a member of the G protein-coupled receptor family of transmembrane receptors. It has been reported that GPR6 is both constitutively active but in addition is further activated by sphingosine-1-phosphate.

GPR6 up-regulates cyclic AMP levels and promotes neurite outgrowth.

Ligand

Inverse Agonist

Evolution

Paralogues to GPR6 gene

Source:

See also

Further reading

External links

  • . IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from on 2012-09-02.