Histone H1.3 is a protein encoded by the HIST1H1D gene in humans.

Histones are basic nuclear proteins that play a crucial role in the nucleosome structure of chromosomal fibers in eukaryotes. Two molecules each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped to create repeating units called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and facilitates the compaction of chromatin into higher-order structures. This intronless gene encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails and instead contain a palindromic termination element. This gene is located within the large histone gene cluster on chromosome 6.

Further reading