major histocompatibility complex, class II, DR13
Haplotypes groupsDQA*01:DRB1*1301 to DQA*01:DRB1*1309 DQA*01:DRB1*1310 DQA*01:DRB1*1312 ....
Structure (See HLA-DR)
Identifiersalpha *0101
Symbol(s)[permanent dead link]
EBI-HLA
Identifiersbeta 1 *1301 to *1308 *1310
Symbol(s)[permanent dead link]
EBI-HLA
EBI-HLA2011-05-15 at the Wayback Machine
EBI-HLA2011-05-15 at the Wayback Machine
EBI-HLA
EBI-HLA2007-09-26 at the Wayback Machine
EBI-HLA
Shared data
Locuschr.6

HLA-DR13(DR13) is a HLA-DR serotype that recognizes the DRB1*1301 to *13082, *1310 and some other *13 gene products. DR13 serotype is a split antigen of the older HLA-DR6 serotype group which also contains the similar HLA-DR14 antigens.

Alleles

DR13, DR6 and other serotype recognition of some DRB1*13 alleles
DRB1*DR13DR6DR14Sample
allele%%%size (N)
1301811413788
1302741723081
130369102948
130487127
13055412305
1306789
1307>501
130845559
1310>755

Serotypes are unknown the following alleles: DRB1*1309, *1315 to *1379 DRB1*13 allele group

  • 81 Alleles: 74 proteins
  • DR13 (weak or no DR6) Serotype: *1301, *1302, *1304, *1306, *1307, *1310, *1312 to *1314
  • DR6 (weak DR13) Serotype: *1308
  • DR13&Other serotypes: *1303, *1305, *1311,
  • Serotype unknown: *1309, *1315 to *1374

Disease associations

DRB1*1302 is linked to early childhood myastenia gravis. Alleles of DR13 along with immunization for hepatitis B and C are most protective against the disease.

Extended linkage

DRB1*1302:DQA1*0102:DQB1*0604 Early childhood myastenia gravis

Genetic Linkage

DR13 Haplotypes
DRADRB1DRB3
DR13(6)-DR52*0101*1301*0101
*0101*1301*0201
*0101*1302*0301
DQA1DQB1DRB1
DR13(6)-DQ6(6.3, 1)*0103*0603*1301
DR13(6)-DQ6(6.4, 1)*0102*0604*1302
DR13(6)-DQ6(6.5, 1)*0102*0605*1302
DR13(6)-DQ6(6.9, 1)*0102*0609*1302
HLA-AHLA-BDRB1
A2-Cw5-B44(16)-DR13*02*4402*1301

HLA-DR13 is genetically linked to DR52 and HLA-DQ6 (HLA-DQ1) serotypes.