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HLA-DR5

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Illustration of HLA-DR

HLA-DR5 (DR5) is a broad-antigen serotype that is further split into HLA-DR11 and HLA-DR12 antigen serotypes.

Serology

DR11, DR5 and DR12 recognition of the gene products of some DRB1*11 and DRB1*12 alleles
DRB1*	DR11	DR5	DR12	Sample
allele	%	%	%	size (N)
11:01	92	5		3474
11:02	89	3		430
11:03	89	4		397
11:04	87	4		2119
11:05	75			4
11:06	20	73		15
11:07	>50			1
11:08	>50			2
11:09	80	20		5
				.
	DR12	DR5	DR11	Sample
12:01	83	4	2	893
12:02	89			162
12:03	>50			3
12:06	>50			2

Except for a few DRB1* alleles, the reactivity of DR5 is relatively poor.

Disease associations

DR5 is associated with persistent generalized lymphadenopathy and Kaposi's sarcoma in AIDS, juvenile rheumatoid arthritis, pernicious anemia, Hashimoto's thyroiditis, mycosis fungoides, polyglandular deficiency syndrome, systemic sclerosis, childhood epilepsy, early-onset alopecia areata, short-ragweed Ra6 allergy, primary antiphospholipid syndrome, and increased longevity in the Dutch.

Genetic linkage

HLA-DR5 reactive gene products are linked to serology of HLA-DRB3 (HLA-DR52).