HLA-DR53
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| major histocompatibility complex, class II, DR53 | |
| Haplotypes | DRA*01:DRB4*0101 DRA*01:DRB4*0102 DRA*01:DRB4*0103 DRA*01:DRB4*0104 |
| Structure (See HLA-DR) | |
| Identifiers | alpha *0101 |
| Symbol(s) | [permanent dead link] |
| EBI-HLA | |
| Identifiers | beta 4 *0101 *0102 *0103 *0104 |
| Symbol(s) | [permanent dead link] |
| EBI-HLA | |
| EBI-HLA | |
| EBI-HLA | |
| EBI-HLA | |
| Shared data | |
| Locus | chr.6 |
HLA-DR53 is an HLA-DR serotype that recognizes gene products of HLA-DRB4 locus. There are 13 alleles at this locus that encode 7 proteins.
DRB3, DRB4, and DRB5 are minor DR beta encoding loci, they have been recognized as having distinct evolution. and the DRB4 locus presence is linked to HLA-DR7 seropositivity. The DRB4*locus was apparently duplicated from an ancestor of the DRB1-DRB4 common locus around 5 million years ago.
DRB4 locus is only apparent in a small subset of DQ haplotypes, and most individuals lack DRB4. In addition the level of normal expression is 8 fold lower than the DRB1 in cells which can express both. and lowered because of both transcriptional and post-transcriptional regulation.
Alleles
| DRB4* | DR53 | ? | Sample |
| allele | % | % | size (N) |
| 01:01 | 95 | 38 | |
| 01:03 | 89 | 49 |
DR53 reactive alleles: DRB4*01:01, *01:03
Unknown reactivity: *01:02, *01:04 to *01:07
Null alleles: *01:03:01:02N, 02:01N, *03:01N
Associated diseases
DRB4*01 is positively associated with Erythema multiforme, Crohn's disease, myasthenia gravis, rheumatoid arthritis Hashimoto's thyroiditis, vitiligo, primary biliary cirrhosis, clozapine-induced agranulocytosis, Vogt–Koyanagi–Harada disease,
HLA-DRB1 linkage
HLA-DR53 serotypes (HLA-DRB4) is linked to the following HLADR serotypes (HLA-DRB1) allele groups:
HLA-DR4 - DRB1*04
HLA-DR7 - DRB1*07
HLA-DR9 - DRB1*09