HLTF

Available structuresPDBOrtholog search:List of PDB id codes, , , , , , ,

Available structures

PDBOrtholog search:

List of PDB id codes, , , , , , ,

List of PDB id codes

, , , , , , ,

Identifiers

Aliases, HIP116, HIP116A, HLTF1, RNF80, SMARCA3, SNF2L3, ZBU1, helicase-like transcription factor, helicase like transcription factor

External IDsOMIM: ; MGI: ; HomoloGene: ; GeneCards: ; OMA:

Gene location ( Human )

Chr.Chromosome 3 (human)

Band 3q24 Start 149,030,127 bp

End149,086,554 bp

Gene location ( Mouse )

Chr.Chromosome 3 (mouse)

Band 3 A2|3 6.15 cM Start 20,111,975 bp

End20,172,654 bp

RNA expression pattern

HumanMouse (ortholog)testicle pons lateral nuclear group of thalamus pars compacta Epithelium of choroid plexus pars reticulata subthalamic nucleus superior vestibular nucleus external globus pallidus cerebellar vermissaccule otic placode otic vesicle habenula atrioventricular valve transitional epithelium of urinary bladder mesenteric lymph nodes retinal pigment epithelium blood primitive streak

Human Mouse (ortholog)

testicle pons lateral nuclear group of thalamus pars compacta Epithelium of choroid plexus pars reticulata subthalamic nucleus superior vestibular nucleus external globus pallidus cerebellar vermissaccule otic placode otic vesicle habenula atrioventricular valve transitional epithelium of urinary bladder mesenteric lymph nodes retinal pigment epithelium blood primitive streak

testicle pons lateral nuclear group of thalamus pars compacta Epithelium of choroid plexus pars reticulata subthalamic nucleus superior vestibular nucleus external globus pallidus cerebellar vermis

saccule otic placode otic vesicle habenula atrioventricular valve transitional epithelium of urinary bladder mesenteric lymph nodes retinal pigment epithelium blood primitive streak

Gene ontologyMolecular functioncatalytic activityCellular componentBiological processSources: /

Gene ontology

Molecular functioncatalytic activity

Cellular component

Biological process

Sources: /

OrthologsSpeciesHumanMouseEntrez Ensembl UniProtRefSeq (mRNA)RefSeq (protein)Location (UCSC)PubMed search

Orthologs

Species Human Mouse

Entrez

Ensembl

UniProt

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

PubMed search

Wikidata

View/Edit HumanView/Edit Mouse

Helicase-like transcription factor is an enzyme that in humans is encoded by the HLTF gene.

Function

This gene encodes a member of the SWI/SNF family. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein contains a RING finger DNA binding motif. Two transcript variants encoding the same protein have been found for this gene. However, use of an alternative translation start site produces an isoform that is truncated at the N-terminus compared to the full-length protein.

HLTF is a double-stranded DNA translocase, one of two human homologs of Saccharomyces cerevisiae besides SHPRH (SNF2 histone linker PHD RING helicase), that is able to carry out fork regression, similarly to Rad5.

Interactions

HLTF has been shown to interact with UBE2N, RAD18 and UBE2V2(see also functional and physical associations network : under the option 'search by name' enter 'protein name' of interest, HLTF, klick on 'GO! ', choose 'organism ', klick on 'continue ->').

HLTF

Function

Interactions

Further reading