HMGN1

Identifiers

Aliases, HMG14, high mobility group nucleosome binding domain 1

External IDsOMIM: ; MGI: ; HomoloGene: ; GeneCards: ; OMA:

Gene location ( Human )

Chr.Chromosome 21 (human)

Band 21q22.2 Start 39,342,315 bp

End39,349,647 bp

Gene location ( Mouse )

Chr.Chromosome 16 (mouse)

Band 16 C4|16 56.83 cM Start 95,921,818 bp

End95,928,929 bp

RNA expression patternHumanMouse (ortholog)ventricular zone ganglionic eminence endometrium right uterine tube appendix lymph node olfactory zone of nasal mucosa rectum islet of Langerhans bone marrowneural layer of retina yolk sac ventricular zone embryo embryo genital tubercle tail of embryo lip zygote right kidneyn/a

RNA expression pattern

HumanMouse (ortholog)ventricular zone ganglionic eminence endometrium right uterine tube appendix lymph node olfactory zone of nasal mucosa rectum islet of Langerhans bone marrowneural layer of retina yolk sac ventricular zone embryo embryo genital tubercle tail of embryo lip zygote right kidney

Human Mouse (ortholog)

ventricular zone ganglionic eminence endometrium right uterine tube appendix lymph node olfactory zone of nasal mucosa rectum islet of Langerhans bone marrowneural layer of retina yolk sac ventricular zone embryo embryo genital tubercle tail of embryo lip zygote right kidney

ventricular zone ganglionic eminence endometrium right uterine tube appendix lymph node olfactory zone of nasal mucosa rectum islet of Langerhans bone marrow

neural layer of retina yolk sac ventricular zone embryo embryo genital tubercle tail of embryo lip zygote right kidney

n/a

Gene ontologyMolecular functionCellular componentBiological processSources: /

Gene ontology

Molecular function

Cellular component

Biological process

Sources: /

OrthologsSpeciesHumanMouseEntrez Ensembl UniProtRefSeq (mRNA)RefSeq (protein)Location (UCSC)PubMed search

Orthologs

Species Human Mouse

Entrez

Ensembl

UniProt

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

PubMed search

Wikidata

View/Edit HumanView/Edit Mouse

Non-histone chromosomal protein HMG-14 is a protein that in humans is encoded by the HMGN1 gene.

Function

Chromosomal protein HMG14 and its close analog HMG17 (MIM 163910) bind to the inner side of the nucleosomal DNA, potentially altering the interaction between the DNA and the histone octamer. The 2 proteins may be involved in the process that maintains transcribable genes in a unique chromatin conformation. Their ubiquitous distribution and relative abundance, as well as the high evolutionary conservation of the DNA-binding domain of the HMG14 family of proteins, suggest that they may be involved in an important cellular function.

Interactions

HMGN1 has been shown to interact with YWHAZ.

HMGN1

Function

Interactions

See also

Further reading