ID2

Available structuresPDBOrtholog search:List of PDB id codes

Available structures

PDBOrtholog search:

List of PDB id codes

Identifiers

Aliases, GIG8, ID2A, ID2H, bHLHb26, inhibitor of DNA binding 2, HLH protein, inhibitor of DNA binding 2

External IDsOMIM: ; MGI: ; HomoloGene: ; GeneCards: ; OMA:

Gene location ( Human )

Chr.Chromosome 2 (human)

Band 2p25.1 Start 8,678,845 bp

End8,684,461 bp

Gene location ( Mouse )

Chr.Chromosome 12 (mouse)

Band 12 A1.3|12 8.57 cM Start 25,143,798 bp

End25,147,139 bp

RNA expression pattern

HumanMouse (ortholog)popliteal artery tibial arteries saphenous vein pericardium right lobe of liver granulocyte trachea lower lobe of lung renal medulla seminal vesiculavas deferens seminal vesicula lobe of cerebellum migratory enteric neural crest cell cerebellar vermis abdominal wall dermis left lung lobe hand parotid gland

Human Mouse (ortholog)

popliteal artery tibial arteries saphenous vein pericardium right lobe of liver granulocyte trachea lower lobe of lung renal medulla seminal vesiculavas deferens seminal vesicula lobe of cerebellum migratory enteric neural crest cell cerebellar vermis abdominal wall dermis left lung lobe hand parotid gland

popliteal artery tibial arteries saphenous vein pericardium right lobe of liver granulocyte trachea lower lobe of lung renal medulla seminal vesicula

vas deferens seminal vesicula lobe of cerebellum migratory enteric neural crest cell cerebellar vermis abdominal wall dermis left lung lobe hand parotid gland

Gene ontologyMolecular functionCellular componentBiological processSources: /

Gene ontology

Molecular function

Cellular component

Biological process

Sources: /

OrthologsSpeciesHumanMouseEntrez Ensembl UniProtRefSeq (mRNA)RefSeq (protein)Location (UCSC)PubMed search

Orthologs

Species Human Mouse

Entrez

Ensembl

UniProt

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

PubMed search

Wikidata

View/Edit HumanView/Edit Mouse

DNA-binding protein inhibitor ID-2 is a protein that in humans is encoded by the ID2 gene.

Function

The protein encoded by this gene belongs to the inhibitor of DNA binding (ID) family, members of which are transcriptional regulators that contain a helix-loop-helix (HLH) domain but not a basic domain. Members of the ID family inhibit the functions of basic helix-loop-helix transcription factors in a dominant-negative manner by suppressing their heterodimerization partners through the HLH domains. This protein may play a role in negatively regulating cell differentiation. A pseudogene has been identified for this gene. The ID2 protein may play a role in the development and resistance to therapies of glioblastoma, the most aggressive of brain cancers.

Interactions

ID2 has been shown to interact with MyoD and NEDD9.

External links

at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Overview of all the structural information available in the PDB for UniProt: (DNA-binding protein inhibitor ID-2) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

ID2

Function

Interactions

See also

Further reading

External links