Interferon gamma receptor 1

IFNGR1

Identifiers

Aliases, CD119, IFNGR, IMD27A, IMD27B, interferon gamma receptor 1

External IDsOMIM: ; MGI: ; HomoloGene: ; GeneCards: ; OMA:

Available structuresPDBOrtholog search:List of PDB id codes, ,

Available structures

PDBOrtholog search:

List of PDB id codes, ,

List of PDB id codes

, ,

Gene location ( Human )

Chr.Chromosome 6 (human)

Band 6q23.3 Start 137,197,483 bp

End137,219,449 bp

Gene location ( Mouse )

Chr.Chromosome 10 (mouse)

Band 10 A3|10 8.49 cM Start 19,467,697 bp

End19,485,977 bp

RNA expression pattern

HumanMouse (ortholog)lower lobe of lung epithelium of nasopharynx right lung jejunal mucosa pericardium human penis palpebral conjunctiva skin of hip monocyte upper lobe of lunglower jaw Meckel's cartilage mandibular molars thymus left colon granulocyte myometrium duodenum tibiofemoral joint lip

Human Mouse (ortholog)

lower lobe of lung epithelium of nasopharynx right lung jejunal mucosa pericardium human penis palpebral conjunctiva skin of hip monocyte upper lobe of lunglower jaw Meckel's cartilage mandibular molars thymus left colon granulocyte myometrium duodenum tibiofemoral joint lip

lower lobe of lung epithelium of nasopharynx right lung jejunal mucosa pericardium human penis palpebral conjunctiva skin of hip monocyte upper lobe of lung

lower jaw Meckel's cartilage mandibular molars thymus left colon granulocyte myometrium duodenum tibiofemoral joint lip

Gene ontologyMolecular functionCellular componentBiological processSources: /

Gene ontology

Molecular function

Cellular component

Biological process

Sources: /

OrthologsSpeciesHumanMouseEntrez Ensembl UniProtRefSeq (mRNA)RefSeq (protein)Location (UCSC)PubMed search

Orthologs

Species Human Mouse

Entrez

Ensembl

UniProt

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

PubMed search

Wikidata

View/Edit HumanView/Edit Mouse

Interferon gamma receptor 1 (IFNGR1) also known as CD119 (Cluster of Differentiation 119), is a protein that in humans is encoded by the IFNGR1 gene.

Function

The gene IFNGR1 encodes IFN-γR1, which is the ligand-binding chain (alpha) of the heterodimeric gamma interferon receptor, which is found on macrophages. IFNGR2, encodes IFN-γR2, the non-ligand-binding partner of the heterodimeric receptor.

Interactions

Interferon gamma receptor 1 has been shown to interact with Interferon-gamma.

Mutations

Mutations in the IFNGR1 gene can lead to extreme susceptibility to Mycobacterial infections. All known mutations and common variations in the IFNGR1 are present in the IFNGR1 mutation database.

External links

at the U.S. National Library of MedicineMedical Subject Headings(MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.