IGSF8

Identifiers

Aliases, CD316, CD81P3, EWI-2, EWI2, KCT-4, LIR-D1, PGRL, immunoglobulin superfamily member 8

External IDsOMIM: ; MGI: ; HomoloGene: ; GeneCards: ; OMA:

Gene location ( Human )

Chr.Chromosome 1 (human)

Band 1q23.2 Start 160,091,340 bp

End160,098,943 bp

Gene location ( Mouse )

Chr.Chromosome 1 (mouse)

Band 1 H3|1 79.59 cM Start 172,089,208 bp

End172,147,408 bp

RNA expression patternHumanMouse (ortholog)right hemisphere of cerebellum right frontal lobe Brodmann area 9 C1 segment prefrontal cortex cingulate gyrus anterior cingulate cortex putamen hypothalamus nucleus accumbensventricular zone primary visual cortex superior frontal gyrus dorsomedial hypothalamic nucleus dentate gyrus of hippocampal formation granule cell subiculum perirhinal cortex superior colliculus respiratory epithelium nasal epitheliumn/a

RNA expression pattern

HumanMouse (ortholog)right hemisphere of cerebellum right frontal lobe Brodmann area 9 C1 segment prefrontal cortex cingulate gyrus anterior cingulate cortex putamen hypothalamus nucleus accumbensventricular zone primary visual cortex superior frontal gyrus dorsomedial hypothalamic nucleus dentate gyrus of hippocampal formation granule cell subiculum perirhinal cortex superior colliculus respiratory epithelium nasal epithelium

Human Mouse (ortholog)

right hemisphere of cerebellum right frontal lobe Brodmann area 9 C1 segment prefrontal cortex cingulate gyrus anterior cingulate cortex putamen hypothalamus nucleus accumbensventricular zone primary visual cortex superior frontal gyrus dorsomedial hypothalamic nucleus dentate gyrus of hippocampal formation granule cell subiculum perirhinal cortex superior colliculus respiratory epithelium nasal epithelium

right hemisphere of cerebellum right frontal lobe Brodmann area 9 C1 segment prefrontal cortex cingulate gyrus anterior cingulate cortex putamen hypothalamus nucleus accumbens

ventricular zone primary visual cortex superior frontal gyrus dorsomedial hypothalamic nucleus dentate gyrus of hippocampal formation granule cell subiculum perirhinal cortex superior colliculus respiratory epithelium nasal epithelium

n/a

Gene ontologyMolecular functionCellular componentBiological processSources: /

Gene ontology

Molecular function

Cellular component

Biological process

Sources: /

OrthologsSpeciesHumanMouseEntrez Ensembl UniProtRefSeq (mRNA)RefSeq (protein)Location (UCSC)PubMed search

Orthologs

Species Human Mouse

Entrez

Ensembl

UniProt

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

PubMed search

Wikidata

View/Edit HumanView/Edit Mouse

Immunoglobulin superfamily member 8 is a protein that in humans is encoded by the IGSF8 gene. IGSF8 has also been designated as CD316 (cluster of differentiation 316). IGSF8 is an innate immune checkpoint that inhibits the cytotoxic activity of natural killer (NK) cells. IGSF8 acts by binding to the Killer Ig-like Receptor KIR3DL2 (or, in mice, the analogous Klra9 receptor). IGSF8 is frequently overexpressed relative to normal tissues in many cancers, included melanoma, urothelial carcinoma, and breast cancer, and has been proposed as a potential therapeutic target in gliomas. In normal tissues, IGSF8 is highly expressed in the brain, where it may contribute to the immune privilege of the central nervous system.

Cancer biomarker

In gliomas, IGSF8 is strongly correlated with tumor grade and is a potential prognostic marker. IGSF8 is enriched on ovarian cancer-derived extracellular vesicles and is a potential biomarker for the early detection of high grade serous ovarian cancer.

External links

at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

IGSF8

Cancer biomarker

Further reading

External links